ENDOTHELIN-1 STIMULATES ARACHIDONATE 15-LIPOXYGENASE ACTIVITY AND OXYGEN RADICAL FORMATION IN THE RAT DISTAL LUNG

被引：70

作者：

NAGASE, T ^{[1
]}

FUKUCHI, Y ^{[1
]}

JO, C ^{[1
]}

TERAMOTO, S ^{[1
]}

UEJIMA, Y ^{[1
]}

ISHIDA, K ^{[1
]}

SHIMIZU, T ^{[1
]}

ORIMO, H ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT PHYSIOL CHEM & NUTR,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92347-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of intravenous bolus of endothelin-1 on the metabolism of eicosanoids and oxygen radicals in the distal lung unit of the rat. Intravenous bolus of endothelin-1 caused a significant increase in 15-hydroxyeicosatetraenoic acid of bronchoalveolar lavage fluid and oxygen radicals produced by the bronchoalveolar cells. Endothelin-1 exhibited a stimulatory effect on the 15-lipoxygenase activity in the lung homogenate. Thus, endothelin-1 may contribute to the inflammatory and hyperreactive process of lungs, by enhancing the release of 15-hydroxyeicosatetraenoic acid and oxygen radicals in the distal lung unit. © 1990.

引用

页码：485 / 489

页数：5

共 15 条

[1] FREE CELLS IN LUNGS - SOME ASPECTS OF THEIR ROLE, QUANTITATION, AND REGULATION [J].

BRAIN, JD .

ARCHIVES OF INTERNAL MEDICINE, 1970, 126 (03) :477-+

[2] THE ACTIONS OF 5-HETE, 12-HETE, AND 15-HETE ON TRACHEOBRONCHIAL SMOOTH-MUSCLE [J].

COPAS, JL ;

BORGEAT, P ;

GARDINER, PJ .

PROSTAGLANDINS LEUKOTRIENES AND MEDICINE, 1982, 8 (02) :105-114

[3]

DENUCCI G, 1988, P NATL ACAD SCI USA, V85, P9797

[4]

JOHNSON HG, 1985, AM REV RESPIR DIS, V131, P917

[5]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[6] EFFECTS OF ARACHIDONIC-ACID, MONOHYDROXYEICOSATETRAENOIC ACID AND PROSTAGLANDINS ON THE RELEASE OF MUCOUS GLYCOPROTEINS FROM HUMAN AIRWAYS INVITRO [J].

MAROM, Z ;

SHELHAMER, JH ;

KALINER, M .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (06) :1695-1702

[7]

MATSUSE T, 1989, American Review of Respiratory Disease, V139, pA497

[8] SUPEROXIDE GENERATION AND ITS MODULATION BY ADENOSINE IN THE NEUTROPHILS OF SUBJECTS WITH ASTHMA [J].

MELTZER, S ;

GOLDBERG, B ;

LAD, P ;

EASTON, J .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1989, 83 (05) :960-966

[9] FREE-RADICALS AND INFLAMMATION - SUPEROXIDE-DEPENDENT ACTIVATION OF A NEUTROPHIL CHEMOTACTIC FACTOR IN PLASMA [J].

PETRONE, WF ;

ENGLISH, DK ;

WONG, K ;

MCCORD, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (02) :1159-1163

[10] RAPID EXTRACTION OF OXYGENATED METABOLITES OF ARACHIDONIC-ACID FROM BIOLOGICAL SAMPLES USING OCTADECYLSILYL SILICA [J].

POWELL, WS .

PROSTAGLANDINS, 1980, 20 (05) :947-957

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