(-) DEPRENYL INDUCES ACTIVITIES OF BOTH SUPEROXIDE-DISMUTASE AND CATALASE BUT NOT OF GLUTATHIONE-PEROXIDASE IN THE STRIATUM OF YOUNG MALE-RATS

被引：247

作者：

CARRILLO, MC ^{[1
]}

KANAI, S ^{[1
]}

NOKUBO, M ^{[1
]}

KITANI, K ^{[1
]}

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, DEPT CLIN PHYSIOL, ITABASHI KU, TOKYO 173, JAPAN

来源：

LIFE SCIENCES | 1991年 / 48卷 / 06期

关键词：

D O I：

10.1016/0024-3205(91)90466-O

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was also increased significantly by deprenyl treatment. The results confirmed the previous findings of Knoll (1) on SOD activity and furthermore provided evidence that the activity of catalase is also significantly induced by the drug, which was not found in the previous study (1).

引用

页码：517 / 521

页数：5

共 11 条

[1]

BEERS RF, 1952, J BIOL CHEM, V195, P133

[2] INCREASED LIFE EXPECTANCY RESULTING FROM ADDITION OF L-DEPRENYL TO MADOPAR TREATMENT IN PARKINSONS-DISEASE - A LONGTERM STUDY [J].