SYNTHESIS AND RELATIVE URINARY EXCRETION RATES OF ENANTIOMERS OF WARFARIN-4-14C AND PHENPROCOUMON-2-14C

被引：20
作者：
GODING, LA
WEST, BD
机构：
[1] Department of Chemistry, University of New Mexico, Albuquerque
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期
关键词：
D O I：
10.1021/jm00303a609
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The enantiomers of warfarin-4-14C (3-α-acetonylbenzyl-4-hydroxycoumarm) and phenprocoumon-2-14C (3-α-ethylbenzyl-4-hydroxycoumarin) have been prepared. The urinary excretion rates of the separate isomers in the rat were not sufficiently different to explain their differences in anticoagulant potencies. No activity was detected in expired CO2 from phenprocoumon-2-14C. © 1969, American Chemical Society. All rights reserved.
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页码：517 / &
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