IDENTIFICATION OF MEDICINAL BARBITURATES BY MEANS OF MASS SPECTROMETRY

被引：34

作者：

COUTTS, RT

LOCOCK, RA

机构：

[1] Faculty of Pharmacy, University of Alberta, Edmonton, Alberta

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 12期

关键词：

Barbiturates—identification; Dosage forms; barbiturates—analysis; Electron impact—barbiturate fragmentation; Mass spectroscopy—identity; structure;

D O I：

10.1002/jps.2600571215

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The mass spectra of the eight barbiturates most commonly prescribed in North America (amobarbital, barbital, butabarbital, mephobarbital, pentobarbital, phenobarbital, secobarbital, and thiopental) and, for comparison purposes, the spectra of butethal (butobarbitone B.P.) and itobarbital were recorded. The weakly acidic material present in capsules or tablets of four different barbiturate‐containing products was extracted into ether and the mass spectrum of each extract was recorded. Evidence is presented that it is possible to identify positively individual barbiturates, and mixtures of barbiturates in pharmaceutical dosage forms, by means of mass spectrometry. The mass spectrum of phenacetin (present in one of the capsules studied) is discussed. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：2096 / &