REGULATION OF THE BIOSYNTHESIS OF AMINOACYL TRANSFER RNA-SYNTHETASES AND OF TRANSFER-RNA IN ESCHERICHIA-COLI .4. MUTANTS WITH INCREASED LEVELS OF LEUCYL-TRANSFER RNA OR SERYL-TRANSFER RNA-SYNTHETASE

被引：11
作者：
THEALL, G
LOW, KB
SOLL, D
机构：
[1] YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06520
[2] YALE UNIV,DEPT THERAPEUT RADIOL,NEW HAVEN,CT 06520
来源：
MOLECULAR & GENERAL GENETICS | 1979年 / 169卷 / 02期
关键词：
D O I：
10.1007/BF00271672
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Spontaneous revertants of a temperature-sensitive Escherichia coli strain harboring a thermolabile leucyl-tRNA synthetase and seryl-tRNA synthetase were selected for growth at 40°C. Among these, strains were found with increased levels of both thermolabile synthetases. Two distinct genetic loci were found responsible for enzyme overproduction. leuR, located near xyl, causes elevated levels of leucyl-tRNA synthetase; while serR, located near leu, causes elevated levels of seryl-tRNA synthetase. © 1979 Springer-Verlag.
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页码：205 / 211
页数：7
相关论文
共 18 条
[1]   GENETIC VARIATION IN THE SEX FACTOR OF ESCHERICHIA-COLI [J].
ADELBERG, EA ;
BURNS, SN .
JOURNAL OF BACTERIOLOGY, 1960, 79 (03) :321-330
[2]   RECALIBRATED LINKAGE MAP OF ESCHERICHIA-COLI K-12 [J].
BACHMANN, BJ ;
LOW, KB ;
TAYLOR, AL .
BACTERIOLOGICAL REVIEWS, 1976, 40 (01) :116-167
[3]   CLOSE LINKAGE OF GENES SER-C (FOR PHOSPHOHYDROXY PYRUVATE TRANSAMINASE) AND SER-S (FOR SERYL-TRANSFER RIBONUCLEIC-ACID SYNTHETASE) IN ESCHERICHIA-COLI K-12 [J].
CLARKE, SJ ;
LOW, B ;
KONIGSBERG, WH .
JOURNAL OF BACTERIOLOGY, 1973, 113 (03) :1091-1095
[4]   SPECTROPHOTOMETRIC DETERMINATION OF MICROGRAM QUANTITIES OF PROTEIN WITHOUT NUCLEIC ACID INTERFERENCE [J].
GROVES, WE ;
DAVIS, FC ;
SELLS, BH .
ANALYTICAL BIOCHEMISTRY, 1968, 22 (02) :195-&
[5]   BIOCHEMICAL AND GENETIC STUDIES WITH LYSINE + METHIONINE MUTANTS OF ESCHERICHIA COLI - LIPOIC ACID AND ALPHA-KETOGLUTARATE DEHYDROGENASE-LESS MUTANTS [J].
HERBERT, AA ;
GUEST, JR .
JOURNAL OF GENERAL MICROBIOLOGY, 1968, 53 :363-+
[6]   REGULATION OF BIOSYNTHESIS OF AMINOACYL-TRANSFER-RNA SYNTHETASES AND OF TRANSFER-RNA IN ESCHERICHIA-COLI .2. ISOLATION OF REGULATORY MUTANTS AFFECTING LEUCYL-TRANSFER-RNA SYNTHETASE LEVELS [J].
LAROSSA, R ;
VOGELI, G ;
LOW, KB ;
SOLL, D .
JOURNAL OF MOLECULAR BIOLOGY, 1977, 117 (04) :1033-1048
[7]   ISOLATION AND PARTIAL CHARACTERIZATION OF TEMPERATURE-SENSITIVE ESCHERICHIA-COLI MUTANTS WITH ALTERED LEUCYL-TRANSFER AND SERYL-TRANSFER RIBONUCLEIC ACID SYNTHETASES [J].
LOW, B ;
GATES, F ;
GOLDSTEIN, T ;
SOLL, D .
JOURNAL OF BACTERIOLOGY, 1971, 108 (02) :742-+
[8]   RAPID MAPPING OF CONDITIONAL AND AUXOTROPHIC MUTATIONS IN ESCHERICHIA-COLI K-12 [J].
LOW, B .
JOURNAL OF BACTERIOLOGY, 1973, 113 (02) :798-812
[9]   ESCHERICHIA-COLI K-12 F-PRIME FACTORS, OLD AND NEW [J].
LOW, KB .
BACTERIOLOGICAL REVIEWS, 1972, 36 (04) :587-607
[10]  
Morgan S D, 1978, Prog Nucleic Acid Res Mol Biol, V21, P181, DOI 10.1016/S0079-6603(08)60270-6
12