How to stop: the mysterious links among RNA polymerase II occupancy 3 vertical bar of genes, mRNA 3 ' processing and termination

被引：12
作者：
Anamika, Krishanpal [1 ]
Gyenis, Akos [1 ]
Tora, Laszlo [1 ]
机构：
[1] Univ Strasbourg, IGBMC, CNRS UMR 7104, INSERM,U964, Illkirch Graffenstaden, France
来源：
TRANSCRIPTION-AUSTIN | 2013年 / 4卷 / 01期
关键词：
genome-wide mapping; RNA Polymerase II pause; core histone genes; End of Annotated Gene; polyadenylation; transcription termination; R-loops;
D O I：
10.4161/trns.22300
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic genes are transcribed by RNA polymerase II (RNAP II) through cycles of initiation, elongation and termination. Termination remains the least understood stage of transcription. Here we discuss the role of RNAP II occupancy downstream of the 3' ends of genes and its links with termination and mRNA 3' processing.
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页码：7 / 12
页数：6
相关论文
共 36 条
[1]   RNA Polymerase II Pausing Downstream of Core Histone Genes Is Different from Genes Producing Polyadenylated Transcripts [J].
Anamika, Krishanpal ;
Gyenis, Akos ;
Poidevin, Laetitia ;
Poch, Olivier ;
Tora, Laszlo .
PLOS ONE, 2012, 7 (06)
[2]   Connections between mRNA 3′ end processing and transcription termination [J].
Buratowski, S .
CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (03) :257-261
[3]   Transcription regulation through promoter-proximal pausing of RNA polymerase II [J].
Core, Leighton J. ;
Lis, John T. .
SCIENCE, 2008, 319 (5871) :1791-1792
[4]   Formation of the 3′ end of histone mRNA [J].
Dominski, Z ;
Marzluff, WF .
GENE, 1999, 239 (01) :1-14
[5]   Formation of the 3′ end of histone mRNA:: Getting closer to the end [J].
Dominski, Zbigniew ;
Marzluff, William F. .
GENE, 2007, 396 (02) :373-390
[6]   Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II [J].
Dye, MJ ;
Proudfoot, NJ .
CELL, 2001, 105 (05) :669-681
[7]   Terminal exon definition occurs contrascriptionally and promotes termination of RNA polymerase II [J].
Dye, MJ ;
Proudfoot, NJ .
MOLECULAR CELL, 1999, 3 (03) :371-378
[8]   Gene Looping Is Conferred by Activator-dependent Interaction of Transcription Initiation and Termination Machineries [J].
El Kaderi, Belal ;
Medler, Scott ;
Raghunayakula, Sarita ;
Ansari, Athar .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (37) :25015-25025
[9]   Ultrastructural study of transcription factories in mouse erythroblasts [J].
Eskiw, Christopher H. ;
Fraser, Peter .
JOURNAL OF CELL SCIENCE, 2011, 124 (21) :3676-3683
[10]   Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks [J].
Gilchrist, Daniel A. ;
Fromm, George ;
dos Santos, Gilberto ;
Pham, Linh N. ;
McDaniel, Ivy E. ;
Burkholder, Adam ;
Fargo, David C. ;
Adelman, Karen .
GENES & DEVELOPMENT, 2012, 26 (09) :933-944
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