THE HUMAN GENE ENCODING THE LARGEST SUBUNIT OF RNA-POLYMERASE-II

被引：15

作者：

MITA, K

TSUJI, H

MORIMYO, M

TAKAHASHI, E

NENOI, M

ICHIMURA, S

YAMAUCHI, M

HONGO, E

HAYASHI, A

机构：

[1] NATL INST RADIOL SCI, DIV GENET, INAGE KU, CHIBA 263, JAPAN

[2] OTSUKA PHARMACEUT CO LTD, Kawaguchi, TOKUSHIMA 77101, JAPAN

[3] NATL INST RADIOL SCI, SCH TRAINING, INAGE KU, CHIBA 263, JAPAN

来源：

GENE | 1995年 / 159卷 / 02期

关键词：

NUCLEOTIDE SEQUENCING; RPII; GENE STRUCTURE;

D O I：

10.1016/0378-1119(95)00081-G

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The nucleotide sequence of a large portion of the human RNA polymerase II large subunit (RpII LS)-encoding gene and its whole gene structure were determined, The RpIILS gene consists of 29 exons. The sequence of the 5' flanking region is highly conserved as compared with that of the mouse RpIILS and contains several SP1-binding sites, a CCAAT sequence and a sequence homologous to a heat-shock element, In addition, several inverted repeats and palindrome sequences were involved in the 5' upstream region, Those suggest that the 5' flanking domain of RpIILS would be highly structured which may be responsible for transcriptional regulation.

引用

页码：285 / 286

页数：2

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