NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF HUMAN CYSTEINYL-TRANSFER-RNA SYNTHETASE

被引：7
|
作者：
CRUZEN, ME
ARFIN, SM
机构：
[1] Department of Biological Chemistry, College of Medicine, University of California, Irvine, CA
来源：
DNA SEQUENCE | 1994年 / 4卷 / 04期
关键词：
AMINOACYL-TRANSFER-RNA SYNTHETASE; HUMAN; NUCLEOTIDE SEQUENCE; AMINO ACID SEQUENCE;
D O I：
10.3109/10425179409020847
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have determined the nucleotide sequence of a cDNA coding human cysteinyl-tRNA synthetase. The predicted protein sequence of 638 amino acids has substantial sequence similarity to the E. coli cysteinyl-tRNA synthetase in the nucleotide-binding fold region that constitutes the potential active site. The results are consistent with the hypothesis that evolution of the full complement of aminoacyl-tRNA synthetases occurred prior to the divergence of prokaryotes and eukaryotes.
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页码：243 / 248
页数：6
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