CYTOTOXIC BIFLAVONOIDS FROM SELAGINELLA-WILLDENOWII

被引：120

作者：

SILVA, GL

CHAI, HY

GUPTA, MP

FARNSWORTH, NR

CORDELL, GA

PEZZUTO, JM

BEECHER, CWW

KINGHORN, AD

机构：

[1] UNIV ILLINOIS, COLL PHARM, DEPT MED CHEM & PHARMACOGNOSY, PROGRAM COLLABORAT RES PHARMACEUT SCI, CHICAGO, IL 60612 USA

[2] UNIV PANAMA, FAC FARM, CIFLORPAN, PANAMA CITY, PANAMA

来源：

PHYTOCHEMISTRY | 1995年 / 40卷 / 01期

关键词：

SELAGINELLA WILLDENOWII; SELAGINELLACEAE; PTERIDOPHYTE; LEAVES; CYTOTOXIC BIFLAVONES; 2'; 3''-DIHYDROISOCRYPTOMERIN; C-13; NMR;

D O I：

10.1016/0031-9422(95)00212-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioactivity-guided fractionation of the leaves of Selaginella willdenowii afforded three known biflavones, 4',7''-di-O-methylamentoflavone, isocryptomerin and 7''-O-methylrobustaflavone, that were significantly cytotoxic against a panel of human cancer cell lines. Non-cytotoxic isolates were also obtained, namely, amentoflavone, bilobetin, robustaflavone and 2'',3''-dihydroisocryptomerin, a new dihydrobiflavone. The structure for the new biflavonoid was unambiguously assigned by a combination of spectroscopic methods.

引用

页码：129 / 134

页数：6

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