PHTHOXAZOLIN-A, A SPECIFIC INHIBITOR OF CELLULOSE BIOSYNTHESIS FROM MICROBIAL ORIGIN .1. DISCOVERY, TAXONOMY OF PRODUCING MICROORGANISM, FERMENTATION, AND BIOLOGICAL-ACTIVITY

被引:41
作者
TANAKA, Y
KANAYA, I
TAKAHASHI, Y
SHINOSE, M
TANAKA, H
OMURA, S
机构
[1] KITASATO INST,BIOL FUNCT RES CTR,9-1 SHIROKANE 5-CHOME,MINATO KU,TOKYO 108,JAPAN
[2] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN
关键词
D O I
10.7164/antibiotics.46.1208
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A new inhibitor of cellulose biosynthesis named phthoxazolin A was discovered as a metabolite of Streptomyces sp. OM-5714. A newly established screening method, which utilized a cellulose-containing fungus, Phytophthora sp. as a test organism, was successfully empolyed for discovery of the compound. Phthoxazolin A, C16H22N2O3 (MW of 290), is a lipophilic triene compound with an oxazole moiety. It has moderate antifungal activity against Phytophthora spp. only and has potent herbicidal activity. Phosphate-limited fermentation conditions favored production of the active compound.
引用
收藏
页码:1208 / 1213
页数:6
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