CHEMICAL-STIMULATION OF THE NUCLEUS LOCUS-CERULEUS - CARDIOVASCULAR-RESPONSES AND BAROREFLEX MODIFICATION

被引：27
作者：
MURASE, S [1 ]
TAKAYAMA, M [1 ]
NOSAKA, S [1 ]
机构：
[1] MIE UNIV,SCH MED,DEPT PSYCHIAT,TSU,MIE 514,JAPAN
来源：
NEUROSCIENCE LETTERS | 1993年 / 153卷 / 01期
关键词：
AORTIC DEPRESSOR NERVE; BAROREFLEX; GLUTAMATE; HOMOCYSTEIC ACID; LOCUS-CERULEUS; NUCLEUS-TRACTUS-SOLITARIUS;
D O I：
10.1016/0304-3940(93)90062-P
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Microinjection of glutamate (Glu, 2.5 nmol) or homocysteic acid (HA, 0.1-0.5 nmol) into the nucleus locus coeruleus (LC) decreased both blood pressure and heart rate. These microinjections also produced a facilitatory or occlusive effect on depressor and bradycardiac responses evoked by electrical stimulation of the aortic depressor nerve (ADN). Destruction of the nucleus tractus solitarius (NTS), which totally eliminated ADN-evoked responses, had no effect on the cardiovascular responses evoked by LC stimulation. These results suggest that the neuronal populations that contribute to the LC-induced cardiovascular responses overlap at least partly with the baroreflex substrate other than the NTS.
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页码：1 / 4
页数：4
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