STIMULATION OF HUMAN NEUTROPHIL PHAGOCYTOSIS OF CANDIDA-ALBICANS BY A BETA-GLUCAN SYNTHASE INHIBITOR, CILOFUNGIN

被引：2

作者：

RICHARDSON, MD

SMYTH, LA

SHANKLAND, GS

机构：

[1] Medical Mycology Unit, Department of Dermatology, University of Glasgow, Glasgow

来源：

FEMS MICROBIOLOGY IMMUNOLOGY | 1991年 / 76卷 / 05期

关键词：

CANDIDA-ALBICANS; HUMAN NEUTROPHIL PHAGOCYTOSIS; CILOFUNGIN;

D O I：

10.1016/0378-1097(91)90032-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of a lipopeptide antifungal agent, cilofungin, on serum opsonization and phagocytosis of Candida albicans yeast phase cells in human neutrophil monolayer assays was investigated. Simultaneous addition of fungicidal concentrations of cilofungin did not enhance or inhibit phagocytosis of C. albicans. Pretreatment of Candida blastospores with cilofungin in the absence of serum complement for 1 h did not affect phagocytosis. However, pretreatment of blastospores with cilofungin and complement promoted a significant increase in ingestion. Pretreatment of neutrophils with cilofungin in serum-free media did not affect neutrophil viability. In contrast, pre-exposure of neutrophils to cilofungin in the presence of complement inhibited ingestion of blastospores.

引用

页码：299 / 303

页数：5

共 8 条

[1]

Domer J. E., 1989, Immunology of the fungal diseases., P57

[2]

DROUHET E, 1990, J MED VET MYCOL, V28, P425

[3] INVITRO EFFECT OF ITRACONAZOLE, KETOCONAZOLE AND AMPHOTERICIN-B ON THE PHAGOCYTIC AND CANDIDACIDAL FUNCTION OF HUMAN-NEUTROPHILS [J].