D-VALUE DETERMINATIONS ARE AN INAPPROPRIATE MEASURE OF DISINFECTING ACTIVITY OF COMMON CONTACT-LENS DISINFECTING SOLUTIONS

被引:19
|
作者
SUTTON, SVW
FRANCO, RJ
PORTER, DA
MOWREYMCKEE, MF
BUSSCHAERT, SC
HAMBERGER, JF
PROUD, DW
机构
关键词
D O I
10.1128/AEM.57.7.2021-2026.1991
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Determination of a D value for specific test organisms is a component of the efficacy evaluation of new contact lens disinfecting solutions. This parameter is commonly defined as the time required for the number of surviving microorganisms to decrease 1 logarithmic unit. The assumption made in establishing a D value is that the rate of kill exhibits first-order kinetics under the specified conditions. Such exponential kill rates are seen with thermal contact lens disinfection systems. A comparison of the death rate kinetics for a variety of chemical contact lens disinfecting solutions was undertaken to ascertain the suitability of D-value determination for these chemical disinfectants. The active agents of these different solutions included hydrogen peroxide, thimerosal, chlorhexidine, tris(2-hydroxyethyl)tallow ammonium chloride, thimerosal, polyaminopropyl biguanide, and polyquaternium-1. The solutions were challenged with 10(6) CFU of either Pseudomonas aeruginosa, Serratia marcescens, or Staphylococcus hominis per ml, and survival rate was determined. This study clearly demonstrates the nonlinear nature of the inactivation curves for most contact lens chemical disinfecting solutions for the challenge organisms. D-value determination is, therefore, an inappropriate method of reporting the biocidal activity of these solutions.
引用
收藏
页码:2021 / 2026
页数:6
相关论文
共 46 条
  • [1] EFFICACY OF CONTACT-LENS DISINFECTING SOLUTIONS FOR PREVENTION OF ACANTHAMOEBA KERATITIS
    HARF, C
    REVIEWS OF INFECTIOUS DISEASES, 1991, 13 : S413 - S413
  • [2] SUSCEPTIBILITY OF ACANTHAMOEBA-CASTELLANII TO CONTACT-LENS DISINFECTING SOLUTIONS
    ZANETTI, S
    FIORI, PL
    PINNA, A
    USAI, S
    CARTA, F
    FADDA, G
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (07) : 1596 - 1598
  • [3] Acanthamoeba and disinfecting contact lens solutions
    Pinna, A
    BRITISH JOURNAL OF OPHTHALMOLOGY, 2002, 86 (12) : 1461 - 1462
  • [4] EFFICACY OF CONTACT-LENS DISINFECTING SOLUTIONS ON PSEUDOMONAS-AERUGINOSA BIOFILMS GROWING ON CONTACT-LENS STORAGE CASE PLASTICS
    EVANS, E
    DART, KG
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1995, 36 (04) : S1018 - S1018
  • [5] Amoebicidal Effects of Contact Lens Disinfecting Solutions
    Boost, Maureen V.
    Shi, Guang-Sen
    Lai, Sindy
    Cho, Pauline
    OPTOMETRY AND VISION SCIENCE, 2012, 89 (01) : 44 - 51
  • [6] DISINFECTING ULTRAVIOLET-LIGHT IN A CONTACT-LENS CARE SYSTEM
    ADMONI, MM
    BARTOLOMEI, A
    ALCARAZ, LG
    ASBELL, PA
    JUSTIN, N
    BOTTONE, EJ
    PRESS, L
    SOLOMON, J
    GRANT, S
    LEGERTON, J
    DUZMAN, E
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1994, 35 (04) : 2163 - 2163
  • [7] Acanthamoeba keratitis and contact lens disinfecting solutions
    Tzanetou, K.
    Miltsakakis, D.
    Droutsas, D.
    Alimisi, S.
    Petropoulou, D.
    Ganteris, G.
    Dolapsaki, E.
    Markomichelakis, N.
    Mallias, I.
    Malamou-Lada, E.
    OPHTHALMOLOGICA, 2006, 220 (04) : 238 - 241
  • [8] NEUTRALIZATION EFFICACY OF DEY-ENGLEY MEDIUM IN TESTING OF CONTACT-LENS DISINFECTING SOLUTIONS
    SUTTON, SVW
    WRZOSEK, T
    PROUD, DW
    JOURNAL OF APPLIED BACTERIOLOGY, 1991, 70 (04): : 351 - 354
  • [9] Cytotoxicity and antimicrobial activity of six multipurpose soft contact lens disinfecting solutions
    Santodomingo-Rubido, Jacinto
    Mori, Osamu
    Kawaminami, Satoshi
    OPHTHALMIC AND PHYSIOLOGICAL OPTICS, 2006, 26 (05) : 476 - 482
  • [10] Impact of contact lens group on antifungal efficacy of multipurpose disinfecting contact lens solutions
    Ide, Takeshi
    Miller, Darlene
    Alfonso, Eduardo C.
    O'Brien, Terrence P.
    EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE, 2008, 34 (03): : 151 - 159