REVERSIBLE HYPOPHOSPHATEMIC RICKETS FOLLOWING IFOSFAMIDE TREATMENT

被引：21

作者：

VANGOOL, S ^{[1
]}

BROCK, P ^{[1
]}

WIJNDAELE, G ^{[1
]}

VANDECASSEYE, W ^{[1
]}

KRUGER, M ^{[1
]}

PROESMANS, W ^{[1
]}

VANDAELE, MC ^{[1
]}

机构：

[1] UNIV HOSP LEUVEN,DEPT PEDIAT,HEREST 49,B-3000 LOUVAIN,BELGIUM

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1992年 / 20卷 / 03期

关键词：

NEPHROTOXICITY OF IFOSFAMIDE; IFOSFAMIDE AND FANCONI SYNDROME; IFOSFAMIDE AND HYPOPHOSPHATEMIC RICKETS;

D O I：

10.1002/mpo.2950200316

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 7-year-old boy developed renal tubular dysfunction and hypophosphatemic rickets following treatment for relapsed embryonal rhabdomyosarcoma. Multi-agent chemotherapy included ifosfamide; the child received a total of 108 g/m2. The complete Fanconi syndrome which ensued, including excessive loss of calcium, resolved spontaneously and progressively 18 months after the last dose of ifosfamide. The patient had no further symptoms of rickets and radiological signs had almost completely normalized. Further follow-up was not possible as, despite further treatment, the child died of progressive disease.

引用

页码：254 / 257

页数：4

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