FORMIC-ACID TREATMENT EXPOSES HIDDEN NEUROFILAMENT AND TAU EPITOPES IN ABNORMAL CYTOSKELETAL FILAMENTS FROM PATIENTS WITH PROGRESSIVE SUPRANUCLEAR PALSY AND ALZHEIMERS-DISEASE

被引：30

作者：

CAMMARATA, S ^{[1
]}

MANCARDI, G ^{[1
]}

TABATON, M ^{[1
]}

机构：

[1] UNIV GENOA,INST NEUROL,VIA DE TONI 5,I-16132 GENOA,ITALY

来源：

NEUROSCIENCE LETTERS | 1990年 / 115卷 / 2-3期

关键词：

Formic acid; Neurofibrillary tangle; Neurofilament; Paired helical filament; Straight filament; Tau protein;

D O I：

10.1016/0304-3940(90)90481-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In cases of progressive supranuclear palsy (PSP) and Alzheimer's disease (AD) the treatment of tissue sections with formic acid (FA) disclosed a neurofilament epitope in subcortical straight (SF) and paired helical (PHF) filaments. The same treatment produced a two-fold increase of tau-reactive neuropil threads and plaque-related neurites in AD cortical tissue. These findings indicate that epitopes of cytoskeletal proteins are hidden by the beta-pleated conformation of SF and PHF components. FA treatment should be used in immunohistochemical detection of intraneuronal abnormal cytoskeletal filaments. © 1990.

引用

页码：351 / 355

页数：5

共 17 条

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[15] PROGRESSIVE SUPRANUCLEAR PALSY - EXTENSIVE NEUROPIL THREADS IN ADDITION TO NEUROFIBRILLARY TANGLES - VERY SIMILAR ANTIGENICITY OF SUBCORTICAL NEURONAL PATHOLOGY IN PROGRESSIVE SUPRANUCLEAR PALSY AND ALZHEIMERS-DISEASE
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