FORMIC-ACID TREATMENT EXPOSES HIDDEN NEUROFILAMENT AND TAU EPITOPES IN ABNORMAL CYTOSKELETAL FILAMENTS FROM PATIENTS WITH PROGRESSIVE SUPRANUCLEAR PALSY AND ALZHEIMERS-DISEASE

被引：30
作者：
CAMMARATA, S [1 ]
MANCARDI, G [1 ]
TABATON, M [1 ]
机构：
[1] UNIV GENOA,INST NEUROL,VIA DE TONI 5,I-16132 GENOA,ITALY
来源：
NEUROSCIENCE LETTERS | 1990年 / 115卷 / 2-3期
关键词：
Formic acid; Neurofibrillary tangle; Neurofilament; Paired helical filament; Straight filament; Tau protein;
D O I：
10.1016/0304-3940(90)90481-N
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In cases of progressive supranuclear palsy (PSP) and Alzheimer's disease (AD) the treatment of tissue sections with formic acid (FA) disclosed a neurofilament epitope in subcortical straight (SF) and paired helical (PHF) filaments. The same treatment produced a two-fold increase of tau-reactive neuropil threads and plaque-related neurites in AD cortical tissue. These findings indicate that epitopes of cytoskeletal proteins are hidden by the beta-pleated conformation of SF and PHF components. FA treatment should be used in immunohistochemical detection of intraneuronal abnormal cytoskeletal filaments. © 1990.
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页码：351 / 355
页数：5
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