CDNA-ENCODING MURINE FK506-BINDING PROTEIN (FKBP) - NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES

被引：32
作者：
NELSON, PA
LIPPKE, JA
MURCKO, MA
ROSBOROUGH, SL
PEATTIE, DA
机构：
[1] Immunology, Molecular Biology and Molecular Modeling, Vertex Pharmaceutical Incorporated, Cambridge
来源：
GENE | 1991年 / 109卷 / 02期
关键词：
RECOMBINANT DNA; IMMUNOBLOTTING; IMMUNOPHILIN; IMMUNOSUPPRESSION; RAPAMYCIN;
D O I：
10.1016/0378-1119(91)90617-K
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A FKBP cDNA encoding murine FK506 binding protein (FKBP) has been cloned, and its complete nucleotide sequence has been determined. The open reading frame within the 1556-bp cDNA segment encodes an 108 amino acid (aa) protein that differs from the human FKBP by three aa and from the bovine FKBP by five aa. Molecular modeling of the protein places the aa substitutions at positions not directly involved in drug binding or interaction with the potential drug target protein, calcineurin A.
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收藏
页码：255 / 258
页数：4
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