RECOMBINANT TOXINS AS NOVEL THERAPEUTIC AGENTS

被引：312
作者：
PASTAN, I
CHAUDHARY, V
FITZGERALD, DJ
机构：
[1] Laboratory of Molecular Biology, Div. Cancer Biol., Diagn./Centers, National Institutes of Health, Bethesda, MD 20829
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 1992年 / 61卷
关键词：
IMMUNOTOXIN; CANCER; RICIN; PSEUDOMONAS EXOTOXIN; DIPHTHERIA TOXIN;
D O I：
10.1146/annurev.bi.61.070192.001555
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：331 / 354
页数：24
相关论文
共 160 条
[61]   PROTEIN ENGINEERING OF ANTIBODY-BINDING SITES - RECOVERY OF SPECIFIC ACTIVITY IN AN ANTI-DIGOXIN SINGLE-CHAIN FV ANALOG PRODUCED IN ESCHERICHIA-COLI [J].
HUSTON, JS ;
LEVINSON, D ;
MUDGETTHUNTER, M ;
TAI, MS ;
NOVOTNY, J ;
MARGOLIES, MN ;
RIDGE, RJ ;
BRUCCOLERI, RE ;
HABER, E ;
CREA, R ;
OPPERMANN, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) :5879-5883
[62]   FUNCTIONAL DOMAINS OF PSEUDOMONAS EXOTOXIN IDENTIFIED BY DELETION ANALYSIS OF THE GENE EXPRESSED IN ESCHERICHIA-COLI [J].
HWANG, J ;
FITZGERALD, DJ ;
ADHYA, S ;
PASTAN, I .
CELL, 1987, 48 (01) :129-136
[63]   LOW PH-INDUCED CHANGES IN PSEUDOMONAS EXOTOXIN AND ITS DOMAINS - INCREASED BINDING OF TRITON-X-114 [J].
IDZIOREK, T ;
FITZGERALD, D ;
PASTAN, I .
INFECTION AND IMMUNITY, 1990, 58 (05) :1415-1420
[64]   NAD-DEPENDENT INHIBITION OF PROTEIN-SYNTHESIS BY PSEUDOMONAS-AERUGINOSA TOXIN [J].
IGLEWSKI, BH ;
KABAT, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (06) :2284-2288
[65]   DELIVERY OF NOVEL THERAPEUTIC AGENTS IN TUMORS - PHYSIOLOGICAL BARRIERS AND STRATEGIES [J].
JAIN, RK .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (08) :570-576
[66]  
JIANG JX, 1990, J BIOL CHEM, V265, P8636
[67]  
JINNO Y, 1989, J BIOL CHEM, V264, P15953
[68]  
JINNO Y, 1988, J BIOL CHEM, V263, P13203
[69]  
JOHNSON VG, 1988, J BIOL CHEM, V263, P1295
[70]   STRUCTURE OF RICIN A-CHAIN AT 2.5-A [J].
KATZIN, BJ ;
COLLINS, EJ ;
ROBERTUS, JD .
PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1991, 10 (03) :251-259
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