AFFINITY OF HUMAN-LEUKOCYTE INTERFERON FOR POLYRIBONUCLEOTIDES

被引：1
|
作者：
CHADHA, KC
GROB, PM
机构：
[1] Roswell Park Memorial Institute Viral Oncology Department Buffalo
来源：
CELL BIOLOGY INTERNATIONAL REPORTS | 1979年 / 3卷 / 08期
关键词：
D O I：
10.1016/0309-1651(79)90097-3
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Human leukocyte interferon (HL-IF) binds to AGPOLY(A)™, AGPOLY(U)™ and AGPOLY(I)™. The bound interferon could be displaced from all three polyribonucleotides by including sodium chloride in the eluant. The nature of interaction of HL-IF with polyribonucleotides is electrostatic and not hydrophobic since its binding was not prevented in the presence of 50% ethylene glycol. The binding of HL-IF on AGPOLY(I)™ is stronger at lower pH since an increase in ionic strength is required to displace it. © 1979.
引用
收藏
页码：663 / 669
页数：7
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