CHARACTERIZATION OF A PLASMA FACTOR HAVING OPIATE AND IMMUNOACTIVITY LIKE BETA-ENDORPHIN

被引：7
作者：
HO, WKK
KWOK, KY
LAM, S
机构：
[1] Department of Biochemistry The Chinese University of Hong Kong, Shatin, New Territories
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 02期
关键词：
D O I：
10.1016/0006-291X(79)91816-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A factor from human plasma having opiate-like activity was characterized in the present study. In addition to its ability to inhibit the binding of [3H]-methionine-enkephalin to opiate receptors, it also cross-reacted with two β-endorphin specific anti-sera. Compared with β-endorphin, the plasma factor had a shorter action on inhibiting the contraction of the guinea pig ileum. By gel-filtration chromatography, the size of this factor was intermediate between that of β-endorphin and methionine-enkephalin. © 1979.
引用
收藏
页码：448 / 454
页数：7
相关论文
共 19 条
[1]   C FRAGMENT OF LIPOTROPIN HAS A HIGH AFFINITY FOR BRAIN OPIATE RECEPTORS [J].
BRADBURY, AF ;
SMYTH, DG ;
SNELL, CR ;
BIRDSALL, NJM ;
HULME, EC .
NATURE, 1976, 260 (5554) :793-795
[2]   OPIATE RECEPTOR AFFINITIES AND BEHAVIORAL-EFFECTS OF ENKEPHALIN - STRUCTURE-ACTIVITY RELATIONSHIP OF 10 SYNTHETIC PEPTIDE ANALOGS [J].
CHANG, JK ;
FONG, BTW ;
PERT, A ;
PERT, CB .
LIFE SCIENCES, 1976, 18 (12) :1473-1481
[3]   ANTIBODIES AS A MEANS OF ISOLATING AND CHARACTERIZING BIOLOGICALLY-ACTIVE SUBSTANCES - PRESENCE OF A NON-PEPTIDE, MORPHINE-LIKE COMPOUND IN CENTRAL NERVOUS-SYSTEM [J].
GINTZLER, AR ;
LEVY, A ;
SPECTOR, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (06) :2132-2136
[4]  
GUILLEMIN R, 1976, CR ACAD SCI D NAT, V282, P783
[5]   IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY [J].
HUGHES, J ;
SMITH, TW ;
KOSTERLITZ, HW ;
FOTHERGILL, LA ;
MORGAN, BA ;
MORRIS, HR .
NATURE, 1975, 258 (5536) :577-579
[6]  
JEFFCOATE WJ, 1978, 60TH END SOC M
[7]   EFFECTS OF ADRENALINE, NORADRENALINE AND ISOPRENALINE ON INHIBITORY ALPHA-AND BETA-ADRENOCEPTORS IN LONGITUDINAL MUSCLE OF GUINEA-PIG ILEUM [J].
KOSTERLITZ, HW ;
LYDON, RJ ;
WATT, AJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1970, 39 (02) :398-+
[8]   BETA-LIPOTROPIN AS A PRO-HORMONE FOR MORPHINOMIMETIC PEPTIDES ENDORPHINS AND ENKEPHALINS [J].
LAZARUS, LH ;
LING, N ;
GUILLEMIN, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (06) :2156-2159
[9]  
Li C.H., 1978, Hormonal Proteins and Peptides, V5, P35
[10]   BETA-ENDORPHIN - LACK OF CORRELATION BETWEEN OPIATE ACTIVITY AND IMMUNOREACTIVITY BY RADIOIMMUNOASSAY [J].
LI, CH ;
RAO, AJ ;
DONEEN, BA ;
YAMASHIRO, D .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 75 (03) :576-580
12