SYNTHESIS OF 26,27-DIALKYL ANALOGS OF 1-ALPHA,25-DIHYDROXYVITAMIN D3

被引：0

作者：

EGUCHI, T ^{[1
]}

SAI, H ^{[1
]}

TAKATSUTO, S ^{[1
]}

HARA, N ^{[1
]}

IKEKAWA, N ^{[1
]}

机构：

[1] TOKYO INST TECHNOL, DEPT CHEM, TOKYO 152, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1988年 / 36卷 / 07期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1.alpha.,25-Dihydroxy-26,27-dimethylvitamin D3 (5), 1.alpha.,25-dihydroxy-26,27-diethylvitamin D3 (6), 25-hydroxy-26,27-dimethylvitamin D3 (7), and 1.alpha.-hydroxy-26,27-dimethylvitamin D3 (8), as dialkyl analogues of 1.alpha.,25-dihydroxyvitamin D3 (1), were synthesized starting from 3.beta.-hydroxycholenic acid (9). When tested for ability to increase serum calcium concentration in rats, 5 was slightly less active than 1, whereas 6 was much less active. Compound 8 was less active than 1.alpha.-hydroxyvitamin D3. In test for ability to induce cell differentiation of HL-60, 5 was 2.5 times and 6 was 12.5 times more active than 1.

引用

页码：2303 / 2311

页数：9

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