DESIGN OF SPECIFIC MECHANISM-BASED INACTIVATORS OF HEPATIC AND ADRENAL MICROSOMAL CYTOCHROMES-P-450 RESPONSIBLE FOR PROGESTERONE 21-HYDROXYLATION

被引：2

作者：

HALPERT, JR ^{[1
]}

JAW, JY ^{[1
]}

JOHNSON, EF ^{[1
]}

机构：

[1] SCRIPPS CLIN & RES FDN,RES INST,DEPT BASIC & CLIN RES,DIV BIOCHEM,LA JOLLA,CA 92037

来源：

DRUG METABOLISM REVIEWS | 1989年 / 20卷 / 2-4期

关键词：

D O I：

10.3109/03602538909103567

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：645 / 655

页数：11

共 20 条

[1] SPECIFIC INACTIVATION BY 17-BETA-SUBSTITUTED STEROIDS OF RABBIT AND RAT-LIVER CYTOCHROMES-P-450 RESPONSIBLE FOR PROGESTERONE 21-HYDROXYLATION
HALPERT, J
JAW, JY
BALFOUR, C
MOLECULAR PHARMACOLOGY, 1989, 35 (01) : 139 - 147
[2] CHLORAMPHENICOL ANALOGS AS MECHANISM-BASED INACTIVATORS OF RAT-LIVER CYTOCHROMES-P-450
MILLER, N
BALFOUR, C
HALPERT, J
FEDERATION PROCEEDINGS, 1986, 45 (03) : 320 - 320
[3] SELECTIVE INACTIVATION BY 21-CHLORINATED STEROIDS OF RABBIT LIVER AND ADRENAL MICROSOMAL CYTOCHROMES-P-450 INVOLVED IN PROGESTERONE HYDROXYLATION
HALPERT, J
JAW, JY
BALFOUR, C
MASH, EA
JOHNSON, EF
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 264 (02) : 462 - 471
[4] DICHLOROMETHYL COMPOUNDS AS MECHANISM-BASED INACTIVATORS OF RAT-LIVER CYTOCHROMES-P-450 INVITRO
HALPERT, JR
BALFOUR, C
MILLER, NE
KAMINSKY, LS
MOLECULAR PHARMACOLOGY, 1986, 30 (01) : 19 - 24
[5] PRIMARY AND SECONDARY PROGESTERONE HYDROXYLATION BY THE RABBIT LIVER MICROSOMAL CYTOCHROMES-P-450 SYSTEM
SENCIALL, IR
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1987, 28 (06) : 711 - 716
[6] DIHALOMETHYL COMPOUNDS AS MECHANISM-BASED INACTIVATORS OF CYTOCHROMES-P450
HALPERT, JR
STEVENS, JC
METHODS IN ENZYMOLOGY, 1991, 206 : 540 - 548
[7] Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin
Di Re, J
Lee, C
Riddick, DS
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1999, 77 (08) : 589 - 597
[8] CLONING AND EXPRESSION OF CDNA-ENCODING A BOVINE ADRENAL CYTOCHROME-P-450 SPECIFIC FOR STEROID 21-HYDROXYLATION (P-450C21)
WHITE, PC
NEW, MI
DUPONT, B
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1984, 435 (DEC) : 229 - 230
[9] REGIOSPECIFIC HYDROXYLATION OF LAURIC ACID AT THE (OMEGA-1) POSITION BY HEPATIC AND KIDNEY MICROSOMAL CYTOCHROMES-P-450 FROM RAINBOW-TROUT
WILLIAMS, DE
OKITA, RT
BUHLER, DR
MASTERS, BSS
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1984, 231 (02) : 503 - 510
[10] Structure and Function of Cytochromes P450 2B: From Mechanism-Based Inactivators to X-Ray Crystal Structures and Back
Halpert, James R.
DRUG METABOLISM AND DISPOSITION, 2011, 39 (07) : 1113 - 1121

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