HUMAN AUTOANTIBODY PRODUCTION IN THE SEVERE COMBINED IMMUNODEFICIENCY (SCID) MOUSE

被引：0
|
作者：
DICKEY, WD
HARLEY, JB
SCOFIELD, RH
机构：
[1] OKLAHOMA MED RES FDN,ARTHRITIS & IMMUNOL PROGRAM,DIGEST DIS & NUTR SECT,OKLAHOMA CITY,OK 73104
[2] OKLAHOMA MED RES FDN,ARTHRITIS & IMMUNOL PROGRAM,ENDOCRINOL SECT,OKLAHOMA CITY,OK 73104
[3] OKLAHOMA MED RES FDN,ARTHRITIS & IMMUNOL PROGRAM,ALLERGY IMMUNOL & RHEUMATOL SECT,OKLAHOMA CITY,OK 73104
[4] UNIV OKLAHOMA,HLTH SCI CTR,DEPT INTERNAL MED,OKLAHOMA CITY,OK 73190
[5] VET ADM MED CTR,OKLAHOMA CITY,OK 73104
来源：
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 1994年 / 12卷 / 02期
关键词：
SCID MICE; SYSTEMIC LUPUS ERYTHEMATOSUS; ANTI-RO;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We investigated the production of autoantibodies in severe combined immunodeficient (scid) mice that received an intraperitoneal injection of peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus. Mice receiving 50 x 10(6) cells consistently engrafted, as evidenced by the presence of human immunoglobulin in the hu-PBL-scid serum; though none, any one, or a combination of the autoantibody specificities found in the donor could be found in the hu-PBL-scid serum. Production of anti-Ro antibody in the hu-PBL-scid chimeric mice could be enhanced by treatment with the Ro antigen. These results indicate that not only can scid mice engrafted with PBMC from patients with SLE produce autoantibody, but also that this production can be manipulated with specific antigen.
引用
收藏
页码：157 / 161
页数：5
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