CRYSTAL-STRUCTURE OF HUMAN CHORIONIC-GONADOTROPIN

被引：791
作者：
LAPTHORN, AJ
HARRIS, DC
LITTLEJOHN, A
LUSTBADER, JW
CANFIELD, RE
MACHIN, KJ
MORGAN, FJ
ISAACS, NW
机构：
[1] UNIV GLASGOW,DEPT CHEM,GLASGOW G12 8QQ,SCOTLAND
[2] COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10032
[3] ST VINCENTS INST MED RES,MELBOURNE,VIC 3065,AUSTRALIA
[4] LATROBE UNIV,DEPT BIOCHEM,MELBOURNE,VIC 3083,AUSTRALIA
来源：
NATURE | 1994年 / 369卷 / 6480期
关键词：
D O I：
10.1038/369455a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif Is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.
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页码：455 / 461
页数：7
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