CRYSTAL-STRUCTURE OF HUMAN CHORIONIC-GONADOTROPIN

被引：794

作者：

LAPTHORN, AJ

HARRIS, DC

LITTLEJOHN, A

LUSTBADER, JW

CANFIELD, RE

MACHIN, KJ

MORGAN, FJ

ISAACS, NW

机构：

[1] UNIV GLASGOW,DEPT CHEM,GLASGOW G12 8QQ,SCOTLAND

[2] COLUMBIA UNIV,DEPT MED,NEW YORK,NY 10032

[3] ST VINCENTS INST MED RES,MELBOURNE,VIC 3065,AUSTRALIA

[4] LATROBE UNIV,DEPT BIOCHEM,MELBOURNE,VIC 3083,AUSTRALIA

来源：

NATURE | 1994年 / 369卷 / 6480期

关键词：

D O I：

10.1038/369455a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The three-dimensional structure of human chorionic gonadotropin shows that each of its two different subunits has a similar topology, with three disulphide bonds forming a cystine knot. This same folding motif Is found in some protein growth factors. The heterodimer is stabilized by a segment of the beta-subunit which wraps around the alpha-subunit and is covalently linked like a seat belt by the disulphide Cys 26-Cys 110. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones.

引用

页码：455 / 461

页数：7

共 51 条

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