PROTEINS THAT INTERACT WITH THE PORE-FORMING SUBUNITS OF VOLTAGE-GATED ION CHANNELS

被引：36
作者：
ADELMAN, JP
机构：
[1] Vollum Institute, Oregon Health Sciences University L-474, Portland, OR 97201-3098
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 03期
关键词：
D O I：
10.1016/0959-4388(95)80040-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Voltage-gated ion channels are composed of pore-forming subunits, as well as auxiliary subunits that modify the functions of these channels. In addition, the channels interact with other modulatory proteins in a more transient manner, although with significant effects on channel activity. Even though many second-messenger systems influence the voltage-gated ion channels, only in a few cases has clear evidence for direct protein-protein interactions been demonstrated. Recent biochemical and genetic studies have helped to elucidate the scope of the interactions between these ion channels and various modulatory proteins by determining the structures and functions of nonpore-forming subunits.
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页码：286 / 295
页数：10
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