PROTEINS THAT INTERACT WITH THE PORE-FORMING SUBUNITS OF VOLTAGE-GATED ION CHANNELS

被引：36
作者：
ADELMAN, JP
机构：
[1] Vollum Institute, Oregon Health Sciences University L-474, Portland, OR 97201-3098
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1995年 / 5卷 / 03期
关键词：
D O I：
10.1016/0959-4388(95)80040-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Voltage-gated ion channels are composed of pore-forming subunits, as well as auxiliary subunits that modify the functions of these channels. In addition, the channels interact with other modulatory proteins in a more transient manner, although with significant effects on channel activity. Even though many second-messenger systems influence the voltage-gated ion channels, only in a few cases has clear evidence for direct protein-protein interactions been demonstrated. Recent biochemical and genetic studies have helped to elucidate the scope of the interactions between these ion channels and various modulatory proteins by determining the structures and functions of nonpore-forming subunits.
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收藏
页码：286 / 295
页数：10
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共 83 条
[1]  
Beneski, Catterall, Covalent labeling of protein components of the sodium channel with a photoactivatable derivative of scorpion toxin, Proc Natl Acad Sci USA, 77, pp. 639-643, (1980)
[2]  
Hartshorne, Catterall, The sodium channel from rat brain, J Biol Chem, 259, pp. 1667-1675, (1984)
[3]  
Messner, Catterall, The sodium channel from rat brain. Separation and characterization of subunits, J Biol Chem, 260, pp. 10597-10604, (1985)
[4]  
Roberts, Barchi, The voltage-sensitive sodium channel from rabbit skeletal muscle, J Biol Chem, 262, pp. 2298-2303, (1987)
[5]  
Isom, DeJongh, Patton, Reber, Offord, Charbonneau, Walsh, Goldin, Catterall, Primary structure and functional expression of the β<sub>1</sub> subunit of the rat brain sodium channel, Science, 256, pp. 839-842, (1992)
[6]  
Goldin, Snutch, Lubbert, Dowsett, Marshall, Auld, Downey, Fritz, Lester, Dunn, Et al., Messenger RNA coding for only the α subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes, Proc Natl Acad Sci USA, 83, pp. 7503-7507, (1986)
[7]  
Auld, Goldin, Kratfe, Marshall, Dunn, Catterall, Lester, Davidson, Dunn, A rat brain Na channel α subunit with novel gating properties, Neuron, 1, pp. 449-461, (1988)
[8]  
Krafte, Goldin, Auld, Dunn, Davidson, Lester, Inactivation of cloned Na channels expressed in Xenopus oocytes, The Journal of General Physiology, 96, pp. 689-706, (1990)
[9]  
Patton, Isom, Catterall, Goldin, The adult rat brain β<sub>1</sub> subunit modifies activation and inactivating gating of multiple sodium channel α subunits, J Biol Chem, 269, pp. 17649-17655, (1994)
[10]  
Bennett, Makita, George, A molecular basis for gating mode transitions in human skeletal muscle Na<sup>+</sup> channels, FEBS Lett, 326, pp. 21-24, (1993)
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