(2-PYRIDYL)METHYL, A NOVEL REAGENT FOR O6 PROTECTION OF 2'-DEOXYGUANOSINE

被引：0

作者：

AWASTHI, SK ^{[1
]}

KHANNA, V ^{[1
]}

WATAL, G ^{[1
]}

MISRA, K ^{[1
]}

机构：

[1] UNIV ALLAHABAD,DEPT CHEM,NUCLE ACID RES LAB,ALLAHABAD 211002,UTTAR PRADESH,INDIA

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1993年 / 32卷 / 09期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(2-Pyridyl)methyl group has been successfully used for the protection of O6 function in partially protected 2'-deoxyguanosine via 'Mitsunobu alkylation' to yield the fully protected monomer units for oligonucleotide synthesis. The group is easier to introduce and deprotect under milder conditions using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in anhyd. pyridine. A trimer d(GGA) and hexamer d(GGATCC) have been synthesized using this protected unit without any significant side reactions.

引用

页码：916 / 919

页数：4

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