Back ground and objective: Accelerating wound healing is a very important factor for patients to return to ordinary life. Due to previous studies, Laser seems to have positive modality effect on cutaneous wound healing. This study aims to investigate the effect of infrared light laser on cutaneous surgical wound in hamster and to compare factors such as angiogenesis, number of fibroblasts and collagen formation with control group Materials and methods: This was an experimental study which was carried out with correlation of Quazvin University of medical science with MEHREGAN pet clinic in winter of 2009. Twenty -five suri hamster were randomly allocated in two groups and four parallel wounds was made on their back, Case group was radiated by red-light laser 630 nm. After 2/5/10 and 14 days, skin biopsy were obtained and number of vessels, fibroblast and collagen production were compared with control group. Result: Evaluation of wound in experimental and control groups showed significantly increased number of vesseles and fibroblast as well as collagen production in laser radiating group. Conclusion: Our study suggest that laser therapy can accelerate wound healing in compression with control group.