SYNTHESIS OF N-(9H-XANTHEN-9-YL)AMINOALKANAMIDE AND N-(9H-THIOXANTHEN-9-YL)AMINOALKANAMIDE DERIVATIVES AND THEIR IN-VITRO EVALUATION AS POTENTIAL INTERCALATORS AND ANTITUMOR DRUGS

被引：10

作者：

FILIPPATOS, E ^{[1
]}

PAPADAKIVALIRAKI, A ^{[1
]}

TODOULOU, O ^{[1
]}

JACQUEMINSABLON, A ^{[1
]}

机构：

[1] INST GUSTAVE ROUSSY,UNITE PHYSICOCHIM MACROMOLEC,F-94805 VILLEJUIF,FRANCE

来源：

ARCHIV DER PHARMAZIE | 1994年 / 327卷 / 02期

关键词：

D O I：

10.1002/ardp.19943270202

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of new N-(9H-xanthen-9-yl)aminoalkanamide and N-(9H-thioxanthen-9-yl)aminoalkanamide derivatives was synthesized and evaluated as potential intercalators by measuring their DNA binding affinity. They were also rested for cytotoxic activity against L1210. The results suggest that the cytotoxicity of these molecules was not due to an intercalating mechanism.

引用

页码：61 / 66

页数：6

共 16 条

[11] POTENTIAL ANTITUMOR AGENTS .54. CHROMOPHORE REQUIREMENTS FOR INVIVO ANTITUMOR-ACTIVITY AMONG THE GENERAL-CLASS OF LINEAR TRICYCLIC CARBOXAMIDES [J].

PALMER, BD ;

REWCASTLE, GW ;

ATWELL, GJ ;

BAGULEY, BC ;

DENNY, WA .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (04) :707-712

[12] XANTHONE-2-CARBOXYLIC ACIDS, A NEW SERIES OF ANTIALLERGIC SUBSTANCES [J].

PFISTER, JR ;

ROOKS, WH ;

ROSZKOWSKI, AP ;

VANHORN, A ;

HARRISON, IT ;

FERRARESI, RW .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (10) :1032-+

[13] The use of xanthydrol as a reagent for the characterization of primary amides [J].

Phillips, RF ;

Pitt, BM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1943, 65 :1355-1357

[14] Aryl salicylic acids and its transfer in xanthone (4 article on catalytic effect of copper) [J].

Ullmann, F ;

Zlokasoff, M .

BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1905, 38 :2111-2119

[15] BENZOPYRANOPYRIDINE DERIVATIVES .1. AMINOALKYL DERIVATIVES OF AZAXANTHENES AS BRONCHODILATING AGENTS [J].

VILLANI, FJ ;

MANN, TA ;

WEFER, EA ;

HANNON, J ;

LARCA, LL ;

LANDON, MJ ;

SPIVAK, W ;

VASHI, D ;

TOZZI, S ;

DANKO, G ;

DELPRADO, M ;

LUTZ, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (01) :1-8

[16]

ORG SYNTH, V1, P554

← 1 2 →