CARDIAC-ARRHYTHMIAS AFTER INHALED BRONCHODILATORS IN PATIENTS WITH COPD AND ISCHEMIC-HEART-DISEASE

被引：18

作者：

SEIDER, N ^{[1
]}

ABINADER, EG ^{[1
]}

OLIVEN, A ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL,BNAI ZION MED CTR,FAC MED,DIV CARDIOL,HAIFA,ISRAEL

来源：

CHEST | 1993年 / 104卷 / 04期

关键词：

D O I：

10.1378/chest.104.4.1070

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Selective beta2-agonist aerosols may produce significant cardiovascular effects. In the present study we used Holter monitoring to compare the arrhythmogenic effects of inhaled terbutaline (TE), a beta2-agonist, with that of ipratropium bromide (IB), a nonabsorbable cholinergic drug. Fourteen patients with concomitant obstructive lung disease, ischemic heart disease, and complaints of postinhalation palpitations were studied in a random, double-blind, cross-over fashion. Both drugs significantly improved vital capacity and FEV1. Heart rate and the frequency of premature beats were not significantly affected by the bronchodilators. We conclude that no clear connection between inhaled bronchodilators and arrhythmias could be demonstrated.

引用

页码：1070 / 1074

页数：5

共 18 条

[1] ARRHYTHMIAS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE [J].

BRASHEAR, RE .

MEDICAL CLINICS OF NORTH AMERICA, 1984, 68 (04) :969-981

[2] ARRHYTHMOGENICITY FROM COMBINED BRONCHODILATOR THERAPY IN PATIENTS WITH OBSTRUCTIVE LUNG-DISEASE AND CONCOMITANT ISCHEMIC-HEART-DISEASE [J].

CONRADSON, TB ;

EKLUNDH, G ;

OLOFSSON, B ;

PAHLM, O ;

PERSSON, G .

CHEST, 1987, 91 (01) :5-9

[3]

CRANE J, 1989, LANCET, V1, P917

[4]

DUTT AK, 1983, EUR J RESPIR DIS, V64, P264

[5] COMBINATION OF THEOPHYLLINE AND SALBUTAMOL FOR ARRHYTHMIAS IN SEVERE COPD [J].

EIDELMAN, DH ;

SAMI, MH ;

MCGREGOR, M ;

COSIO, MG .

CHEST, 1987, 91 (06) :808-812

[6] PRESCRIBED FENOTEROL AND DEATH FROM ASTHMA IN NEW-ZEALAND, 1981-7 - A FURTHER CASE-CONTROL STUDY [J].

GRAINGER, J ;

WOODMAN, K ;

PEARCE, N ;

CRANE, J ;

BURGESS, C ;

KEANE, A ;

BEASLEY, R .

THORAX, 1991, 46 (02) :105-111

[7]

KELLY HW, 1985, ANN ALLERGY, V54, P405

[8] CONCOMITANT BITOLTEROL MESYLATE AEROSOL AND THEOPHYLLINE FOR ASTHMA THERAPY, WITH 24-HR ELECTROCARDIOGRAPHIC MONITORING [J].

KEMP, JP ;

CHERVINSKY, P ;

ORGEL, HA ;

MELTZER, EO ;

NOYES, JH ;

MINGO, TS .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1984, 73 (01) :32-43

[9] IPRATROPIUM BROMIDE IN CHRONIC BRONCHITIS/EMPHYSEMA - A REVIEW OF THE LITERATURE [J].

LAKSHMINARAYAN, S .

AMERICAN JOURNAL OF MEDICINE, 1986, 81 (5A) :76-80

[10]

LULICH KM, 1986, MED TOXICOL ADV DRUG, V1, P289

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