CALCITONIN GENE-RELATED PEPTIDE RELAXES CHOLECYSTOKININ-INDUCED CONTRACTION IN GUINEA-PIG GALLBLADDER STRIPS INVITRO

被引:18
|
作者
KLINE, LW
PANG, PKT
机构
[1] Department of Physiology, University of Alberta, Edmonton
关键词
CALCITONIN GENE RELATED PEPTIDE; GALLBLADDER; CHOLECYSTOKININ;
D O I
10.1139/y92-225
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Calcitonin gene related peptide has been shown to relax vascular and intestinal smooth muscle. This study examines the effects of calcitonin gene related peptide on cholecystokinin-induced contraction of guinea pig gallbladder strips in vitro. Calcitonin gene related peptide was found to cause a dose-dependent relaxation of cholecystokinin-induced tension, which was blocked by the calcitonin gene related peptide receptor antagonist human calcitonin gene related peptide8-37. Previous studies demonstrated that calcitonin gene related peptide acted directly on guinea pig gallbladder smooth muscle to inhibit acetylcholine- or KCl-induced contraction. The present results further confirm that calcitonin gene related peptide acts directly on the smooth muscle. In addition, the use of L-N(G)-nitroarginine methyl ester, glibenclamide, and other agents strongly suggests that calcitonin gene related peptide also acts by way of the nonadrenergic noncholinergic nervous system, to induce the relaxation of cholecystokinin-induced contraction observed in the guinea pig gallbladder strips.
引用
收藏
页码:1571 / 1575
页数:5
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