A SUBFRACTION, DERIVED FROM A NON-PROTECTIVE LEISHMANIA-INFANTUM EXTRACT, PROTECTS BALB/C MICE AGAINST LEISHMANIA-MAJOR INFECTION

被引：0

作者：

ROLLAND, L ^{[1
]}

VIJAYALAKSHMI, SVM ^{[1
]}

机构：

[1] UNIV TECHNOL COMPIEGNE,TECHNOL SEPARAT LAB,F-60200 COMPIEGNE,FRANCE

来源：

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1993年 / 316卷 / 11期

关键词：

LEISHMANIASIS; PROTECTION; CD4+ CELLS; CD8+ CELLS; INTERFERON GAMMA;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the identification of a subfraction isolated by gel filtration liquid chromatography from a non-protective Leishmania infantum extract, which protects Balb/c mice against Leishmania major infection, in conjunction with a bacterial adjuvant. Protected mice exhibited cell-mediated immunity, at assessed by increased numbers of CD4(+) and CD8(+) spleen cells, and the production of IFN gamma, as compared to mice who received only the adjuvant before infection.

引用

页码：1342 / 1349

页数：8