A SUBFRACTION, DERIVED FROM A NON-PROTECTIVE LEISHMANIA-INFANTUM EXTRACT, PROTECTS BALB/C MICE AGAINST LEISHMANIA-MAJOR INFECTION

被引：0
作者：
ROLLAND, L [1 ]
VIJAYALAKSHMI, SVM [1 ]
机构：
[1] UNIV TECHNOL COMPIEGNE,TECHNOL SEPARAT LAB,F-60200 COMPIEGNE,FRANCE
来源：
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES | 1993年 / 316卷 / 11期
关键词：
LEISHMANIASIS; PROTECTION; CD4+ CELLS; CD8+ CELLS; INTERFERON GAMMA;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We report the identification of a subfraction isolated by gel filtration liquid chromatography from a non-protective Leishmania infantum extract, which protects Balb/c mice against Leishmania major infection, in conjunction with a bacterial adjuvant. Protected mice exhibited cell-mediated immunity, at assessed by increased numbers of CD4(+) and CD8(+) spleen cells, and the production of IFN gamma, as compared to mice who received only the adjuvant before infection.
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收藏
页码：1342 / 1349
页数：8
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