Vascular invasion affects survival in early hepatocellular carcinoma

被引:39
作者
Hsieh, Chen-Hsi [1 ,2 ,3 ]
Wei, Chang-Kuo [4 ]
Yin, Wen-Yao [4 ]
Chang, Chun-Ming [4 ]
Tsai, Shiang-Jiun [5 ]
Wang, Li-Ying [6 ,7 ]
Chiou, Wen-Yen [5 ]
Lee, Moon-Sing [5 ,8 ]
Lin, Hon-Yi [5 ,8 ]
Hung, Shih-Kai [5 ,8 ]
机构
[1] Far Eastern Mem Hosp, Dept Radiat Oncol, New Taipei 220, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Dept Med, Taipei 112, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Inst Tradit Med, Taipei 112, Taiwan
[4] Buddhist Dalin Tzu Chi Hosp, Dept Gen Surg, Dalin 62247, Chiayi, Taiwan
[5] Buddhist Dalin Tzu Chi Hosp, Dept Radiat Oncol, Dalin 62247, Chiayi, Taiwan
[6] Natl Taiwan Univ Hosp, Coll Med, Sch & Grad Inst Phys Therapy, Taipei 100, Taiwan
[7] Natl Taiwan Univ Hosp, Coll Med, Phys Therapy Ctr, Taipei 100, Taiwan
[8] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan
关键词
hepatocellular carcinoma; surgery; vascular invasion;
D O I
10.3892/mco.2014.420
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hepatocellular carcinoma (HCC) is an aggressive malignant tumor with a high mortality rate. The optimal therapeutic choice for early HCC is surgical resection. However, the rate of intrahepatic recurrence is high. The objective of this study was to evaluate the effect of various factors on the survival of patients with early HCC. Between January 1st, 2006 and December 31st, 2013, a total of 89 patients who underwent surgery for HCC were retrospectively enrolled. The analysis was conducted using the Student's t-test, Chi-square test, Kaplan-Meier method and Cox proportional hazard regression model to assess potential confounding and predictive variables. The 3-year overall survival (OS) rate was 71%. The 3-year OS rates in patients with and those without vascular invasion were 62.1 and 92.8%, respectively (P<0.003). Based on the multivariate analysis, postoperative pathological vascular invasion (hazard ratio =4.96; 95% confidence interval: 1.55-15.9) remained an independent predictor of adverse long-term outcome. Furthermore, vascular invasion was significantly associated with intrahepatic metastasis. These data emphasize the need for effective adjuvant therapy in selected high-risk patients with early HCC. Further studies are required to determine the optimal approach to further improving the prognosis of early HCC.
引用
收藏
页码:252 / 256
页数:5
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