Selective and nonselective HDAC8 inhibitors: a therapeutic patent review

被引：23
|
作者：
Adhikari, Nilanjan [1 ]
Amin, Sk Abdul [1 ]
Jha, Tarun [1 ]
机构：
[1] Jadavpur Univ, Div Med & Pharmaceut Chem, Dept Pharmaceut Technol, Nat Sci Lab, POB 17020, Kolkata 700032, India
来源：
PHARMACEUTICAL PATENT ANALYST | 2018年 / 7卷 / 06期
关键词：
benzamide; cancer; carboxylate; epigenetics; HDAC8; inhibitors; histone deacetylase 8; hydroxamate; selectivity; thiol;
D O I：
10.4155/ppa-2018-0019
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Histone deacetylase 8 (HDAC8) is one of the attractive therapeutic anticancer targets. HDAC8 has been overexpressed in a variety of human cancers. Therefore, HDAC8 inhibitors offer beneficial effects in the treatment of solid and hematological tumors. Different HDAC inhibitors entered into different phases of clinical studies. However, selectivity towards specific HDAC8 enzyme is still demanding. In this patent review, a number of patented selective and nonselective HDAC8 inhibitors along with their implication as anticancer agents have been discussed in details. Molecules should possess modified fish-like structural arrangement to impart potency and selectivity towards HDAC8. This comprehensive patent analysis will surely provide newer aspects of designing selective HDAC8 inhibitors targeted to anticancer therapy in future.
引用
收藏
页码：259 / 276
页数：18
相关论文
共 50 条
  • [31] Effect of two series of isoindolines over HDAC8 activity and expression
    Trejo Munoz, Cynthia R.
    Mera Jimenez, Elvia
    Pinto-Almazan, Rodolfo
    Diaz Gandarilla, Jose Alfredo
    Correa-Basurto, Jose
    Trujillo-Ferrara, Jose G.
    Guerra-Araiza, Christian
    Talamas Rohana, Patricia
    Mancilla Percino, Teresa
    MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (06) : 3227 - 3234
  • [32] Structure-activity relationships of HDAC8 inhibitors: Non-hydroxamates as anticancer agents
    Amin, Sk. Abdul
    Adhikari, Nilanjan
    Jha, Tarun
    PHARMACOLOGICAL RESEARCH, 2018, 131 : 128 - 142
  • [33] Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia
    Weiwer, Michel
    Lewis, Michael C.
    Wagner, Florence F.
    Holson, Edward B.
    FUTURE MEDICINAL CHEMISTRY, 2013, 5 (13) : 1491 - 1508
  • [34] Novel Selective Histone Deacetylase 6 (HDAC6) Inhibitors: A Patent Review (2016-2019)
    He, Xingrui
    Li, Zhen
    Zhuo, Xiao-Tao
    Hui, Zi
    Xie, Tian
    Ye, Xiang-Yang
    RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2020, 15 (01) : 32 - 48
  • [35] Hit Identification and Functional Validation of Novel Dual Inhibitors of HDAC8 and Tubulin Identified by Combining Docking and Molecular Dynamics Simulations
    Curcio, Antonio
    Rocca, Roberta
    Chiera, Federica
    Cantafio, Maria Eugenia Gallo
    Valentino, Ilenia
    Ganino, Ludovica
    Murfone, Pierpaolo
    De Simone, Angela
    Di Napoli, Giulia
    Alcaro, Stefano
    Amodio, Nicola
    Artese, Anna
    ANTIOXIDANTS, 2024, 13 (11)
  • [36] Design, synthesis, and biological evaluation of substituted benzyl-triazolopyridine derivatives as non-hydroxamate based HDAC8 inhibitors
    Bandaru, N. V. M. Rao
    Fathima, Ashna
    Joshi, Vandana
    Schweipert, Markus
    Pathur, Obanna
    Chaitanya, Kosana Sai
    Jamma, Trinath
    Sharma, Vivek
    Abbineni, Chandrasekhar
    Meyer-Almes, Franz-Josef
    Sekhar, Kondapalli Venkata Gowri Chandra
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, 2025, 13
  • [37] Arylcarboxamide Derivatives as Promising HDAC8 Inhibitors: An Overview in Light of Structure-activity Relationship and Binding Mode of Interaction Analysis
    Banerjee, Suvankar
    Baidya, Sandip Kumar
    Jha, Tarun
    Ghosh, Balaram
    Adhikari, Nilanjan
    MEDICINAL CHEMISTRY, 2024,
  • [38] HDAC8 as an emerging target in drug discovery with special emphasis on medicinal chemistry
    Rajaraman, Srinidhi
    Balakrishnan, Ranjani
    Deshmukh, Dhruv
    Ganorkar, Abhiram
    Biswas, Swati
    Pulya, Sravani
    Ghosh, Balaram
    FUTURE MEDICINAL CHEMISTRY, 2023, 15 (10) : 885 - 908
  • [39] Structural exploration of tetrahydroisoquinoline derivatives as HDAC8 inhibitors through multi-QSAR modeling study
    Banerjee, Suvankar
    Adhikari, Nilanjan
    Amin, Sk. Abdul
    Jha, Tarun
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 38 (05) : 1551 - 1564
  • [40] Discovery of highly potent HDAC8 PROTACs with anti-tumor activity
    Zhao, Chunlong
    Chen, Deng
    Suo, Fengzhi
    Setroikromo, Rita
    Quax, Wim J.
    Dekker, Frank J.
    BIOORGANIC CHEMISTRY, 2023, 136
12345