WHOLE-BLOOD GRANULOCYTE AGGREGATION INVITRO IN DIALYSIS-DEPENDENT PATIENTS

被引：3
|
作者：
TAYLOR, JE [1 ]
BRIDGES, A [1 ]
HENDERSON, IS [1 ]
STEWART, WK [1 ]
BELCH, JJF [1 ]
机构：
[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT MED,DUNDEE DD1 9SY,SCOTLAND
来源：
BLOOD COAGULATION & FIBRINOLYSIS | 1991年 / 2卷 / 06期
关键词：
RENAL DIALYSIS; WHITE BLOOD CELL; ARTERIAL DISEASE;
D O I：
10.1097/00001721-199112000-00011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls: 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be one of many factors contributing to their increased cardiovascular morbidity.
引用
收藏
页码：765 / 769
页数：5
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