POLYMER PROTEIN CONJUGATES .1. EFFECT OF PROTEIN CONJUGATION ON THE CLOUD POINT OF POLY(N-ISOPROPYLACRYLAMIDE)

被引：85
作者：
CHEN, JP [1 ]
YANG, HJ [1 ]
HOFFMAN, AS [1 ]
机构：
[1] UNIV WASHINGTON,CTR BIOENGN,FL-20,SEATTLE,WA 98195
来源：
BIOMATERIALS | 1990年 / 11卷 / 09期
关键词：
polymer-protein conjugates; polymers; Proteins;
D O I：
10.1016/0142-9612(90)90019-M
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Poly(N-isopropylacrylamide) (p(NIPAAm)) exhibits a cloud point around 32°C. In this study we have conjugated several proteins to p(NIPAAm), and the effects of protein molecular weight, pH and ionic strength on the cloud point of the p(NIPAAm)-protein conjugates have been studied. The cloud points of p(NIPAAm)-protein conjugates appear to be unaffected by the molecular weight or isoelectric point (pi) of the proteins, the pH or ionic strength. © 1990.
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页码：625 / 630
页数：6
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