EFFECTS OF THE LIPASE INHIBITORS, TRITON-WR-1339 AND TETRAHYDROLIPSTATIN, ON THE SYNTHESIS AND SECRETION OF LIPIDS BY RAT HEPATOCYTES

被引：19

作者：

HERMIER, D

HALES, P

BRINDLEY, DN

机构：

[1] UNIV ALBERTA,FAC MED,HERITAGE MED RES CTR 328,LIPID & LIPOPROTEIN RES GRP,EDMONTON T6G 2S2,ALBERTA,CANADA

[2] UNIV ALBERTA,FAC MED,DEPT BIOCHEM,EDMONTON T6G 2S2,ALBERTA,CANADA

来源：

FEBS LETTERS | 1991年 / 286卷 / 1-2期

关键词：

LIPASE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

D O I：

10.1016/0014-5793(91)80970-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipase inhibitors, Triton WR-1339 and tetrahydrolipstatin, were incubated with rat hepatocytes. Triton WR-1339 increased the recovery of triacylglycerol in the hepatocytes and incubation medium by 31% and 38%, respectively. Tetrahydrolipstatin decreased the accumulation of newly synthesized, and of total triacylglycerol in the medium. This compound might be useful in determining mechanisms involved in intracellular triacylglycerol metabolism and the secretion of very low density lipoproteins.

引用

页码：186 / 188

页数：3

共 18 条

[1]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[2]

BORESZTAJN L, 1976, BIOCHEM J, V156, P539

[3] MODE OF ACTION OF TETRAHYDROLIPSTATIN - A DERIVATIVE OF THE NATURALLY-OCCURRING LIPASE INHIBITOR LIPSTATIN [J].