Aurora B: A new promising therapeutic target in cancer

被引：28

作者：

Chieffi, Paolo ^{[1
]}

机构：

[1] Univ Campania, Dipartimento Psicol, Viale Ellitt 31, I-81100 Caserta, Italy

来源：

INTRACTABLE & RARE DISEASES RESEARCH | 2018年 / 7卷 / 02期

关键词：

Aurora kinase; Aurora B; serine-threonine kinase; mitosis; cytokinesis; cancer; inhibitors;

D O I：

10.5582/irdr.2018.01018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A critical step for maintenance of genetic stability is chromosome segregation, which requires a high coordination of cellular processes. Loss of mitotic regulation is a possible cause of aneuploidy in human epithelial malignancy and it is thought to create an abnormal nuclear morphology in cancer cells. Serine/threonine protein kinase Aurora B gene plays a regulatory role from G2 to cytokinesis, encompassing key cell cycle events such as centrosome duplication, chromosome bi-orientation, and segregation. The overexpression of Aurora B has been observed in several tumour types, and has been linked with a poor prognosis for cancer patients. Therapeutic inhibition of Aurora kinase showed great promise as a probable anticancer regime because of its important role during cell division.

引用

页码：141 / 144

页数：4

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