Network Pharmacology for Traditional Chinese Medicine Research: Methodologies and Applications

被引：25
作者：
Liu, Yu-feng [1 ]
Ai, Ni [1 ]
Keys, Anthony [2 ]
Fan, Xiao-hui [1 ]
Chen, Min-jun [2 ]
机构：
[1] Zhejiang Univ, Pharmaceut Informat Inst, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
[2] US FDA, Div Bioinformat & Biostat, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA
来源：
CHINESE HERBAL MEDICINES | 2015年 / 7卷 / 01期
基金：
中国国家自然科学基金;
关键词：
network pharmacology; network toxicology; traditional Chinese medicine;
D O I：
10.1016/S1674-6384(15)60015-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The inception of network pharmacology comes from the advance in "multi-target, multi-drug" paradigm and opens up a new field for pharmaceutical science. Traditional Chinese medicine (TCM) is well-known for its use of medicinal herb combinations to treat the functional disorders induced by diseases through a holistic view, which naturally followed the principal of network pharmacology. In this review, the methodologies of network pharmacology in TCM studies were summarized. Specifically, the methodologies for network construction and network analysis were discussed in detail by following several TCM study cases. The perspectives for TCM network pharmacology were also provided.
引用
收藏
页码：18 / 26
页数：9
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