ON A PRACTICAL SYNTHESIS OF BETA-HYDROXY FATTY-ACID DERIVATIVES

被引：32

作者：

OIKAWA, M ^{[1
]}

KUSUMOTO, S ^{[1
]}

机构：

[1] OSAKA UNIV,FAC SCI,DEPT CHEM,TOYONAKA,OSAKA 560,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 04期

关键词：

D O I：

10.1016/0957-4166(95)00106-Y

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient synthesis of three homochiral beta-hydroxy fatty acid derivatives, which have been utilized in our total synthesis of lipid A, is reported. The synthesis features Sharpless asymmetric dihydroxylation of an unsaturated ester, regioselective conversion of a diol into acyloxy chlorides, and a reductive removal of the chloro group.

引用

页码：961 / 966

页数：6

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