STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE NON-PEPTIDYL GROWTH-HORMONE SECRETAGOGUE L-692,429

被引：11

作者：

OK, D ^{[1
]}

SCHOEN, WR ^{[1
]}

HODGES, P ^{[1
]}

DEVITA, RJ ^{[1
]}

BROWN, JE ^{[1
]}

CHENG, K ^{[1
]}

CHAN, WWS ^{[1
]}

BUTLER, BS ^{[1
]}

SMITH, RG ^{[1
]}

FISHER, MH ^{[1
]}

WYVRATT, MJ ^{[1
]}

机构：

[1] MERCK & CO INC,MERCK SHARP & DOHME RES LABS,DEPT BASIC ANIM SCI RES,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80702-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Systematic investigation of the amino acid sidechain of L-692,429, the prototype of a novel class of benzolactam growth hormone (GH) secretagogues, has led to the preparation of L-692,585, a 2(R)hydroxypropyl amino analog, which is twenty times more potent in vitro than L-692,429. Additional amino modifications reported here further define the structure-activity profile for L-692,429.

引用

页码：2709 / 2714

页数：6

共 15 条

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