EFFECTS OF RHYNCHOPHYLLINE ON MOTOR-ACTIVITY OF MICE AND SEROTONIN AND DOPAMINE IN RAT-BRAIN

被引：0
|
作者：
SHI, JS
HUANG, B
WU, Q
REN, RX
XIE, XL
机构：
来源：
ACTA PHARMACOLOGICA SINICA | 1993年 / 14卷 / 02期
关键词：
RHYNCHOPHYLLINE; MOTOR ACTIVITY; HYPNOTICS AND SEDATIVES; SEROTONIN; DOPAMINE; CENTRAL NERVOUS SYSTEM;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Rhynchophylline (Rhy) reduced the spontaneous motor activity and enhanced the sedative and hypnotic effects of sodium pentobarbital in mice. The effects of Rhy on serotonin (5-HT) and dopamine (DA) concetrations in rat brain, and the release of 5-HT and DA from the regional brain slices were studied by a fluorescence detector. Rhy increased the 5-HT content in the hypothalamus and cortex, but reduced the DA concentrations in the cortex, amygdala, and spinal cord. Rhy promoted the release of endogenous DA from 4 brain regions. The release of 5-HT was increased in 2 brain regions and decreased in hypothalamus slice. However, Rhy inhibited the release of both 5-HT and DA evoked by high potassium.
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页码：114 / 117
页数：4
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