EFFECTS OF RHYNCHOPHYLLINE ON MOTOR-ACTIVITY OF MICE AND SEROTONIN AND DOPAMINE IN RAT-BRAIN

被引：0
|
作者：
SHI, JS
HUANG, B
WU, Q
REN, RX
XIE, XL
机构：
来源：
ACTA PHARMACOLOGICA SINICA | 1993年 / 14卷 / 02期
关键词：
RHYNCHOPHYLLINE; MOTOR ACTIVITY; HYPNOTICS AND SEDATIVES; SEROTONIN; DOPAMINE; CENTRAL NERVOUS SYSTEM;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Rhynchophylline (Rhy) reduced the spontaneous motor activity and enhanced the sedative and hypnotic effects of sodium pentobarbital in mice. The effects of Rhy on serotonin (5-HT) and dopamine (DA) concetrations in rat brain, and the release of 5-HT and DA from the regional brain slices were studied by a fluorescence detector. Rhy increased the 5-HT content in the hypothalamus and cortex, but reduced the DA concentrations in the cortex, amygdala, and spinal cord. Rhy promoted the release of endogenous DA from 4 brain regions. The release of 5-HT was increased in 2 brain regions and decreased in hypothalamus slice. However, Rhy inhibited the release of both 5-HT and DA evoked by high potassium.
引用
收藏
页码：114 / 117
页数：4
相关论文
共 50 条
  • [31] DIFFERENTIAL-EFFECTS OF ABECARNIL ON BASAL RELEASE OF ACETYLCHOLINE AND DOPAMINE IN THE RAT-BRAIN
    IMPERATO, A
    DAZZI, L
    SERRA, M
    GESSA, GL
    BIGGIO, G
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 261 (1-2) : 205 - 208
  • [32] PRAZOSIN ATTENUATES THE EFFECTS OF COCAINE ON MOTOR-ACTIVITY BUT NOT ON SCHEDULE-CONTROLLED BEHAVIOR IN THE RAT
    BERTHOLD, CW
    GONZALES, RA
    MOERSCHBAECHER, JM
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1992, 43 (01) : 111 - 115
  • [33] NORFLUOXETINE ENANTIOMERS AS INHIBITORS OF SEROTONIN UPTAKE IN RAT-BRAIN
    WONG, DT
    BYMASTER, FP
    REID, LR
    MAYLE, DA
    KRUSHINSKI, JH
    ROBERTSON, DW
    NEUROPSYCHOPHARMACOLOGY, 1993, 8 (04) : 337 - 344
  • [34] EFFECT OF INHIBITING ENKEPHALIN CATABOLISM IN THE VTA ON MOTOR-ACTIVITY AND EXTRACELLULAR DOPAMINE
    DAUGE, V
    KALIVAS, PW
    DUFFY, T
    ROQUES, BP
    BRAIN RESEARCH, 1992, 599 (02) : 209 - 214
  • [35] Role of dopamine in behavioral effects of serotonin microinjected into rat striatum
    Yeghiayan, SK
    Kelley, AE
    Kula, NS
    Campbell, A
    Baldessarini, RJ
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1997, 56 (02) : 251 - 259
  • [36] EFFECTS OF DOPAMINE PARTIAL-AGONIST AMINOERGOLINES ON DOPAMINE METABOLISM IN LIMBIC AND EXTRAPYRAMIDAL REGIONS OF RAT-BRAIN
    BALDESSARINI, RJ
    MARSH, ER
    HUSTONLYONS, D
    BIOCHEMICAL PHARMACOLOGY, 1994, 47 (10) : 1917 - 1919
  • [37] THE NEUROTOXIC EFFECTS OF P-CHLOROAMPHETAMINE IN RAT-BRAIN ARE BLOCKED BY PRIOR DEPLETION OF SEROTONIN
    BERGER, UV
    GRZANNA, R
    MOLLIVER, ME
    BRAIN RESEARCH, 1992, 578 (1-2) : 177 - 185
  • [38] EFFECTS OF SINGLE DOSES AND DAILY MELATONIN TREATMENTS ON SEROTONIN METABOLISM IN RAT-BRAIN REGIONS
    MIGUEZ, JM
    MARTIN, FJ
    ALDEGUNDE, M
    JOURNAL OF PINEAL RESEARCH, 1994, 17 (04) : 170 - 176
  • [39] ETHANOL-INDUCED MOTOR-ACTIVITY IN NORMAL AND ACATALASEMIC MICE
    ARAGON, CMG
    PESOLD, CN
    AMIT, Z
    ALCOHOL, 1992, 9 (03) : 207 - 211
  • [40] THALLIUM INCREASES MONOAMINE-OXIDASE ACTIVITY AND SEROTONIN TURNOVER RATE IN RAT-BRAIN REGIONS
    OSORIORICO, L
    GALVANARZATE, S
    RIOS, C
    NEUROTOXICOLOGY AND TERATOLOGY, 1995, 17 (01) : 1 - 5
12345