COMPARATIVE-STUDIES OF RNA - INFERRING HIGHER-ORDER STRUCTURE FROM PATTERNS OF SEQUENCE VARIATION

被引：76
作者：
GUTELL, RR
机构：
[1] Biology Campus Box 347, University of Colorado, Boulder
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1993年 / 3卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0959-440X(05)80101-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA structural chemistry and evolutionary biology, long considered disparate fields of study, are the topics of this review. Evolution transcends all of the sciences, adding a dimension that enriches every science it touches, and in its enrichment of those fields contributes back to evolutionary thought. RNA, on the other hand, is a molecule with an inordinate number of possible conformations; knowing which to evaluate experimentally is problematic. Analysis of RNA sequences from an evolutionary perspective reveals patterns of variation and sequence constraints, and suggests how an RNA sequence is folded up into its higher-order structure.
引用
收藏
页码：313 / 322
页数：10
相关论文
共 67 条
[51]   STABILITIES OF CONSECUTIVE A.C, C.C, G.G, U.C, AND U.U MISMATCHES IN RNA INTERNAL LOOPS - EVIDENCE FOR STABLE HYDROGEN-BONDED U.U AND C.C+ PAIRS [J].
SANTALUCIA, J ;
KIERZEK, R ;
TURNER, DH .
BIOCHEMISTRY, 1991, 30 (33) :8242-8251
[52]  
SCHULMAN LH, 1991, PROG NUCLEIC ACID RE, V41, P23
[53]   A GENERAL SECONDARY-STRUCTURE MODEL FOR PROCARYOTIC AND EUKARYOTIC RNAS OF THE SMALL RIBOSOMAL-SUBUNITS [J].
STIEGLER, P ;
CARBON, P ;
EBEL, JP ;
EHRESMANN, C .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1981, 120 (03) :487-495
[54]   INVITRO GENETICS [J].
SZOSTAK, JW .
TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (03) :89-93
[55]  
TENDAM E, 1991, NUCLEIC ACIDS RES, V19, P6951
[56]   STRUCTURAL AND FUNCTIONAL-ASPECTS OF RNA PSEUDOKNOTS [J].
TENDAM, E ;
PLEIJ, K ;
DRAPER, D .
BIOCHEMISTRY, 1992, 31 (47) :11665-11676
[57]   RNA PSEUDOKNOTS THAT INHIBIT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE [J].
TUERK, C ;
MACDOUGAL, S ;
GOLD, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) :6988-6992
[58]   CUUCGG HAIRPINS - EXTRAORDINARILY STABLE RNA SECONDARY STRUCTURES ASSOCIATED WITH VARIOUS BIOCHEMICAL PROCESSES [J].
TUERK, C ;
GAUSS, P ;
THERMES, C ;
GROEBE, DR ;
GAYLE, M ;
GUILD, N ;
STORMO, G ;
DAUBENTONCARAFA, Y ;
UHLENBECK, OC ;
TINOCO, I ;
BRODY, EN ;
GOLD, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1364-1368
[59]   STRUCTURE OF AN UNUSUALLY STABLE RNA HAIRPIN [J].
VARANI, G ;
CHEONG, CJ ;
TINOCO, I .
BIOCHEMISTRY, 1991, 30 (13) :3280-3289
[60]   THE DESIGN AND CATALYTIC PROPERTIES OF A SIMPLIFIED RIBONUCLEASE-P RNA [J].
WAUGH, DS ;
GREEN, CJ ;
PACE, NR .
SCIENCE, 1989, 244 (4912) :1569-1571
1234567