Relevance of PET for Pretherapeutic Prediction of Doses in Peptide Receptor Radionuclide Therapy

被引：10
作者：
Blaickner, Matthias [1 ]
Baum, Richard P. [1 ]
机构：
[1] AIT Austrian Inst Technol, Hlth & Environm Dept, Biomed Syst, Donau City Str 1-2, A-1220 Vienna, Austria
来源：
PET CLINICS | 2014年 / 9卷 / 01期
关键词：
Peptide receptor radionuclide therapy; Dosimetry; Pretherapeutic treatment planning; PET/CT; SPECT/CT; Planar imaging; Correlation with clinical response; Radiobiological models;
D O I：
10.1016/j.cpet.2013.08.014
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Personalized dosimetry in radionuclide therapy has gained much attention in recent years. This attention has also an impact on peptide receptor radionuclide therapy (PRRT). This article reviews the PET-based imaging techniques that can be used for pretherapeutic prediction of doses in PRRT. More specifically the usage of Y-86, Y-90, Ga-68, and Sc-44 are discussed: their characteristics for PET acquisition, the available peptides for labeling, the specifics of the imaging protocols, and the experiences gained from phantom and clinical studies. These techniques are evaluated with regard to their usefulness for dosimetry predictions in PRRT, and future perspectives are discussed.
引用
收藏
页码：99 / +
页数：15
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