GENE-EXPRESSION IN CARDIAC-HYPERTROPHY

被引：73
作者：
BOHELER, KR
SCHWARTZ, K
机构：
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1992年 / 2卷 / 05期
关键词：
D O I：
10.1016/1050-1738(92)90046-U
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiac hypertrophy due to hemodynamic overload is a harbinger of morbidity and mortality in humans. The development of hypertrophy involves both quantitative and qualitative changes in gene expression that are thought to produce an enlarged organ more capable of meeting its new functional requirements. The genes are normal, but the way in which they are regulated is modified. Analysis of these changes and the mechanisms involved are essential if we are to understand the role that hypertrophy plays in the pathogenesis of heart failure.
引用
收藏
页码：176 / 182
页数：7
相关论文
共 50 条
[31]   GENE-TRANSFER INTO CARDIAC MYOCYTES INVIVO [J].
LEINWAND, LA ;
LEIDEN, JM .
TRENDS IN CARDIOVASCULAR MEDICINE, 1991, 1 (07) :271-276
[32]  
LOMPRE AM, 1991, INT REV CYTOL, V124, P137
[33]   ALTERED SARCOPLASMIC-RETICULUM CA-2+-ATPASE GENE-EXPRESSION IN THE HUMAN VENTRICLE DURING END-STAGE HEART-FAILURE [J].
MERCADIER, JJ ;
LOMPRE, AM ;
DUC, P ;
BOHELER, KR ;
FRAYSSE, JB ;
WISNEWSKY, C ;
ALLEN, PD ;
KOMAJDA, M ;
SCHWARTZ, K .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (01) :305-309
[34]  
MERCADIER JJ, 1990, RES CARDIAC HYPERTRO, P401
[35]   CARDIAC-HYPERTROPHY - MECHANICAL, NEURAL, AND ENDOCRINE DEPENDENCE [J].
MORGAN, HE ;
BAKER, KM .
CIRCULATION, 1991, 83 (01) :13-25
[36]   MYOSIN ISOZYME SYNTHESIS AND MESSENGER-RNA LEVELS IN PRESSURE-OVERLOADED RABBIT HEARTS [J].
NAGAI, R ;
PRITZL, N ;
LOW, RB ;
STIREWALT, WS ;
ZAK, R ;
ALPERT, NR ;
LITTEN, RZ .
CIRCULATION RESEARCH, 1987, 60 (05) :692-699
[37]   REGULATION OF MYOCARDIAL CA-2+-ATPASE AND PHOSPHOLAMBAN MESSENGER-RNA EXPRESSION IN RESPONSE TO PRESSURE OVERLOAD AND THYROID-HORMONE [J].
NAGAI, R ;
ZARAINHERZBERG, A ;
BRANDL, CJ ;
FUJII, J ;
TADA, M ;
MACLENNAN, DH ;
ALPERT, NR ;
PERIASAMY, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2966-2970
[38]   SIGNAL TRANSDUCTION THROUGH G PROTEINS IN THE CARDIAC MYOCYTE [J].
NEER, EJ ;
CLAPHAM, DE .
TRENDS IN CARDIOVASCULAR MEDICINE, 1992, 2 (01) :6-11
[39]  
ONEILL L, 1991, CARDIOSCIENCE, V2, P1
[40]   SEGREGATION OF ATRIAL-SPECIFIC AND INDUCIBLE EXPRESSION OF AN ATRIAL-NATRIURETIC-FACTOR TRANSGENE IN AN INVIVO MURINE MODEL OF CARDIAC-HYPERTROPHY [J].
ROCKMAN, HA ;
ROSS, RS ;
HARRIS, AN ;
KNOWLTON, KU ;
STEINHELPER, ME ;
FIELD, LJ ;
ROSS, J ;
CHEIN, KR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (18) :8277-8281
12345