IDENTIFICATION OF THE SERUM-RESPONSIVE TRANSCRIPTION INITIATION SITE OF THE ZINC FINGER GENE KROX-20

被引:15
|
作者
CORTNER, J [1 ]
FARNHAM, PJ [1 ]
机构
[1] UNIV WISCONSIN, MCARDLE LAB CANC RES, 1400 UNIV AVE, MADISON, WI 53706 USA
关键词
D O I
10.1128/MCB.10.7.3788
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Krox-20 gene is rapidly and transiently induced when quiescent 3T3 cells are stimulated to reenter the proliferative cycle. We identified the major serum-responsive transcription initiation site and found that it differs from the initiation sites previously identified for the Krox-20 gene. Transcripts from the major serum-responsive initiation site increased at least 40-fold in serum-stimulated cells compared with logarithmically growing cells.
引用
收藏
页码:3788 / 3791
页数:4
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