CAPSAICIN INHIBITS RESPONSES OF FINE AFFERENTS FROM THE KNEE-JOINT OF THE CAT TO MECHANICAL AND CHEMICAL STIMULI

被引：23

作者：

HE, X ^{[1
]}

SCHEPELMANN, K ^{[1
]}

SCHAIBLE, HG ^{[1
]}

SCHMIDT, RF ^{[1
]}

机构：

[1] UNIV WURZBURG,INST PHYSIOL,RONTGENRING 9,W-8700 WURZBURG,GERMANY

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 01期

关键词：

Capsaicin; Cat; Chemosensitivity; Desensitization; Joint afferent; Mechanosensitivity; Nociceptor;

D O I：

10.1016/0006-8993(90)90672-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In adult anaesthetized cats we studied the effects of capsaicin on the responses of single slowly conducting afferents of the knee joint to mechanical and chemical stimuli (bradykinin). An intra-arterial bolus injection of capsaicin into the joint reduced or abolished the responses to passive movements of the joint in 8 of 19 afferents and the responses to intra-arterially administered bradykinin in 10 of 11 units. Capsaicin was usually effective at 10-4 to 10-3 M. The inhibition was predominantly observed in nociceptive afferents, whereas most low threshold units were not desensitized. © 1990.

引用

页码：147 / 150

页数：4

共 37 条

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[32] FOURIER-ANALYSIS OF THE RELATION BETWEEN THE DISCHARGE OF QUADRICEPS MOTOR UNITS AND PERIODIC MECHANICAL STIMULATION OF CAT KNEE-JOINT RECEPTORS
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[34] MECHANICAL SENSITIVITY OF GROUP-III AND GROUP-IV AFFERENTS FROM POSTERIOR ARTICULAR NERVE IN NORMAL AND INFLAMED CAT KNEE
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[37] A novel knee joint model in FEBio with inhomogeneous fibril-reinforced biphasic cartilage simulating tissue mechanical responses during gait: data from the osteoarthritis initiative
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