CAPSAICIN INHIBITS RESPONSES OF FINE AFFERENTS FROM THE KNEE-JOINT OF THE CAT TO MECHANICAL AND CHEMICAL STIMULI

被引：23

作者：

HE, X ^{[1
]}

SCHEPELMANN, K ^{[1
]}

SCHAIBLE, HG ^{[1
]}

SCHMIDT, RF ^{[1
]}

机构：

[1] UNIV WURZBURG,INST PHYSIOL,RONTGENRING 9,W-8700 WURZBURG,GERMANY

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 01期

关键词：

Capsaicin; Cat; Chemosensitivity; Desensitization; Joint afferent; Mechanosensitivity; Nociceptor;

D O I：

10.1016/0006-8993(90)90672-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In adult anaesthetized cats we studied the effects of capsaicin on the responses of single slowly conducting afferents of the knee joint to mechanical and chemical stimuli (bradykinin). An intra-arterial bolus injection of capsaicin into the joint reduced or abolished the responses to passive movements of the joint in 8 of 19 afferents and the responses to intra-arterially administered bradykinin in 10 of 11 units. Capsaicin was usually effective at 10-4 to 10-3 M. The inhibition was predominantly observed in nociceptive afferents, whereas most low threshold units were not desensitized. © 1990.

引用

页码：147 / 150

页数：4

共 37 条

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HE, X
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GASTROENTEROLOGY, 1999, 116 (04) : A1057 - A1057
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ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 1999, 13 (04) : 561 - 566
[25] MITOCHONDRIA IN FINE AFFERENT NERVE-FIBERS OF THE KNEE-JOINT IN THE CAT - A QUANTITATIVE ELECTRON-MICROSCOPIC EXAMINATION
HEPPELMANN, B
MESSLINGER, K
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[26] ENHANCEMENT OF THE RESPONSES OF ASCENDING TRACT CELLS IN THE CAT SPINAL-CORD BY ACUTE-INFLAMMATION OF THE KNEE-JOINT
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EXPERIMENTAL BRAIN RESEARCH, 1987, 66 (03) : 489 - 499
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ANNALS OF EMERGENCY MEDICINE, 1984, 13 (11) : 1065 - 1067
[28] THE INVOLVEMENT OF SUBSTANCE-P AND NEUROKININ-1 RECEPTORS IN THE RESPONSES OF RAT DORSAL HORN NEURONS TO NOXIOUS BUT NOT TO INNOCUOUS MECHANICAL STIMULI APPLIED TO THE KNEE-JOINT
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BRAIN RESEARCH, 1994, 666 (02) : 207 - 215
[29] Histamine excites groups III and IV afferents from the cat knee joint depending on their resting activity
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NEUROSCIENCE LETTERS, 2001, 305 (02) : 95 - 98
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