Inhaled therapy in cystic fibrosis: agents, devices and regimens

被引：53

作者：

Agent, Penny ^{[1
]}

Parrott, Helen ^{[1
]}

机构：

[1] Royal Brompton & Harefield NHS Fdn Trust, London, England

来源：

BREATHE | 2015年 / 11卷 / 02期

关键词：

D O I：

10.1183/20734735.021014

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The recognised mainstay daily treatments for cystic fibrosis (CF) focus on inhaled and oral medications, airway clearance and optimised nutrition. This review discusses recent advances in inhaled therapies for the management of CF, including devices such as intelligent nebulisers, drug formulations and supporting evidence for inhaled antibiotics (for the management of chronic Pseudomonas aeruginosa) and muco-active drugs. We include practical advice for clinicians regarding the optimisation of inhalation technique and education. The influence of adherence on the use of inhaled therapies in CF is also reviewed.

引用

页码：111 / 118

页数：8

共 49 条

[1] Long-Term Inhaled Dry Powder Mannitol in Cystic Fibrosis An International Randomized Study [J].

Aitken, Moira L. ;

Bellon, Gabriel ;

De Boeck, Kris ;

Flume, Patrick A. ;

Fox, Howard G. ;

Geller, David E. ;

Haarman, Eric G. ;

Hebestreit, Helge U. ;

Lapey, Allen ;

Schou, I. Manjula ;

Zuckerman, Jonathan B. ;

Charlton, Brett .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 185 (06) :645-652

[2] Adherence to nebulised therapies in adolescents with cystic fibrosis is best on week-days during school term-time [J].

Ball, Rosemary ;

Southern, Kevin W. ;

McCormack, Pamela ;

Duff, Alistair J. A. ;

Brownlee, Keith G. ;

McNamara, Paul S. .

JOURNAL OF CYSTIC FIBROSIS, 2013, 12 (05) :440-444

[3] Inhaled dry powder mannitol in cystic fibrosis: an efficacy and safety study [J].

Bilton, D. ;

Robinson, P. ;

Cooper, P. ;

Gallagher, C. G. ;

Kolbe, J. ;

Fox, H. ;

Jaques, A. ;

Charlton, B. .

EUROPEAN RESPIRATORY JOURNAL, 2011, 38 (05) :1071-1080

[4]

Bilton D, 2014, J CYST FIBROS, V13, pS65

[5] Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis [J].

Bilton, Diana ;

Bellon, Gabriel ;

Charlton, Brett ;

Cooper, Peter ;

De Boeck, Kris ;

Flume, Patrick A. ;

Fox, Howard G. ;

Gallagher, Charles G. ;

Geller, David E. ;

Haarman, Eric G. ;

Hebestreit, Helge U. ;

Kolbe, John ;

Lapey, Allen ;

Robinson, Phil ;

Wu, Jian ;

Zuckerman, Jonathan B. ;

Aitken, Moira L. .

JOURNAL OF CYSTIC FIBROSIS, 2013, 12 (04) :367-376

[6] Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection [J].

Clancy, J. P. ;

Dupont, L. ;

Konstan, M. W. ;

Billings, J. ;

Fustik, S. ;

Goss, C. H. ;

Lymp, J. ;

Minic, P. ;

Quittner, A. L. ;

Rubenstein, R. C. ;

Young, K. R. ;

Saiman, L. ;

Burns, J. L. ;

Govan, J. R. W. ;

Ramsey, B. ;

Gupta, R. .

THORAX, 2013, 68 (09) :818-825

[7]

Conway SP, 2002, J CYSTIC FIBROSIS S1, V1, pS67

[8]

Cystic fibrosis trust, 2011, STAND CLIN CAR CHILD

[9]

Cystic Fibrosis Trust, 2011, STAND CAR GOOD CLIN

[10] Accurate Assessment of Adherence Self-Report and Clinician Report vs Electronic Monitoring of Nebulizers [J].

Daniels, Tracey ;

Goodacre, Lynne ;

Sutton, Chris ;

Pollard, Kim ;

Conway, Steven ;

Peckham, Daniel .

CHEST, 2011, 140 (02) :425-432

← 1 2 3 4 5 →